Results 261 to 270 of about 4,965,955 (309)

Protein Kinase InhibitorsThe Tyrosine-Specific Protein Kinases

Pharmacology & Therapeutics, 1998
Inhibitors for tyrosine-specific protein kinases ultimately may constitute a novel family of medicinally active agents. Unfortunately, the challenges associated with the acquisition of inhibitors for these enzyme targets are unlike any that have ever been encountered in medicinal chemistry.
D S, Lawrence, J, Niu
openaire   +2 more sources

cAMP-dependent protein kinase and the protein kinase family

Faraday Discussions, 1992
The structure of the catalytic subunit of cAMP-dependent protein kinase, the first protein kinase structure to be solved, is reviewed. The general architecture of the enzyme is described as well as the active site regions associated with substrate binding and catalysis.
S S, Taylor, D R, Knighton, J, Zheng, L F, Ten Eyck, J M, Sowadski   +4 more
openaire   +2 more sources

AGC protein kinase phosphorylation and protein kinase C

Biochemical Society Transactions, 2001
Protein kinase cascades feature in many signal transduction pathways. For those discussed here, a single upstream protein kinase appears to be responsible for the control of multiple downstream targets. So how is specificity introduced into these events?
Parker, P J, Parkinson, S J
openaire   +2 more sources

A-kinase anchoring protein targeting of protein kinase A in the heart

Journal of Molecular and Cellular Cardiology, 2004
There is increasing evidence that subcellular targeting of signaling molecules is an important means of regulating the protein kinase A (PKA) pathway. Subcellular organization of the signaling molecules in the PKA pathway insures that a signal initiated at the receptor level is transferred efficiently to a PKA substrate eliciting some cellular response.
Mary L, Ruehr, Mary A, Russell, Meredith, Bond   +2 more
openaire   +2 more sources

Method for Simultaneous Detection of Protein Kinase A, Protein Kinase C, Protein Tyrosine Kinase, and Calmodulin-Dependent Protein Kinase Activities

Analytical Biochemistry, 1993
We report a simple method that permits simultaneous detection of multiple protein kinase activities using postnuclear supernatant of v-src transformed NIH3T3 cells. A supernatant is incubated with activators of protein kinases and [gamma-32P]ATP, and the phosphorylated proteins are analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis ...
H, Fukazawa, P M, Li, S, Mizuno, Y, Uehara   +3 more
openaire   +2 more sources

Protein Kinases

2011
Enzymes that move phosphate groups from ATP to serine, threonine, or tyrosine residues in another protein.
openaire   +5 more sources

Bacterial Protein Kinases

2021
Bacteria are able to inhabit and survive vastly diverse environments. This enormous adaptive capacity depend on their ability to perceive cues from the micro-environment and process this information accordingly to mount appropriate metabolic responses and ultimately sustain homeostasis.
openaire   +2 more sources

Nuclear protein kinases

Molecular and Cellular Biochemistry, 1984
Nuclear protein kinases include enzymes that transfer the gamma-phosphate of ATP to serine, threonine, lysine or histidine in proteins. Nuclear kinases with a preference for basic proteins are known as histone kinases; those preferring acidic protein substrates are casein kinases.
H R, Matthews, V D, Huebner
openaire   +2 more sources

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Cell, 2021
Trever Bivona, Siyu Feng, Jayanta Debnath   +2 more
exaly  

Kinases (Protein Kinases)

2013
S. Zafar, I. Zerr
openaire   +1 more source