Results 1 to 10 of about 589,206 (164)

Pituitary adenylate cyclase-activating polypeptide type 1 receptor signaling evokes long-lasting nociceptive behaviors through the activation of spinal astrocytes in mice [PDF]

Journal of Pharmacological Sciences, 2016
Intrathecal (i.t.) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) induces long-lasting nociceptive behaviors for more than 60 min in mice, while the involvement of PACAP type1 receptor (PAC1-R) has not been clarified yet ...
Tetsuya Ohnou, Masafumi Yokai, Takashi Kurihara, Maiko Hasegawa-Moriyama, Takao Shimizu, Kazuhiko Inoue, Yuki Kambe, Yuichi Kanmura, Atsuro Miyata   +8 more
doaj   +3 more sources

Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion [PDF]

Viruses
Yaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Dewi Megawati, Jeannine N. Stroup, Chorong Park, Taylor Clarkson, Loubna Tazi, Greg Brennan, Stefan Rothenburg   +6 more
doaj   +2 more sources

Increasing lentiviral vector titer using inhibitors of protein kinase R

BioTechniques, 2004
Gilles Pernod, Richard Fish, Jia Wei Liu, Egbert K.O. Kruithof   +3 more
doaj   +2 more sources

The role of protein kinase R in dystonia

Dystonia, 2023
Dystonia is a progressive neurological motor disease with few treatment options and no cure. This review synthesizes the results of recent studies that implicate protein kinase R in mediating the molecular mechanisms of dystonia pathogenesis.
Benjamin Dodd, Benjamin Dodd, Stephanie L. Moon, Stephanie L. Moon   +3 more
doaj   +1 more source

Antagonism of Protein Kinase R by Large DNA Viruses

Pathogens, 2022
Decades of research on vaccinia virus (VACV) have provided a wealth of insights and tools that have proven to be invaluable in a broad range of studies of molecular virology and pathogenesis.
Annabel T. Olson, Stephanie J. Child, Adam P. Geballe   +2 more
doaj   +1 more source

Protein Kinase R in Bacterial Infections: Friend or Foe?

Frontiers in Immunology, 2021
The global antimicrobial resistance crisis poses a significant threat to humankind in the coming decades. Challenges associated with the development of novel antibiotics underscore the urgent need to develop alternative treatment strategies to combat ...
Robin Smyth, Jim Sun, Jim Sun
doaj   +1 more source

The protein kinase R modifies gut physiology to limit colitis

Frontiers in Immunology, 2023
Here we investigate the function of the innate immune molecule protein kinase R (PKR) in intestinal inflammation. To model a colitogenic role of PKR, we determine the physiological response to dextran sulfate sodium (DSS) of wild-type and two transgenic ...
Howard Chi Ho Yim, Howard Chi Ho Yim, Arindam Chakrabarti, Sean Kessler, Hiroyuki Morimoto, Hiroyuki Morimoto, Die Wang, Die Wang, Dhanya Sooraj, Dhanya Sooraj, Afsar U. Ahmed, Afsar U. Ahmed, Carol de la Motte, Robert H. Silverman, Bryan RG. Williams, Bryan RG. Williams, Anthony J. Sadler, Anthony J. Sadler, Anthony J. Sadler   +18 more
doaj   +1 more source

Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R

Viruses, 2022
Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA ...
M. Julhasur Rahman, Loubna Tazi, Sherry L. Haller, Stefan Rothenburg   +3 more
doaj   +1 more source

Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model

Cardiovascular Therapeutics, 2022
Objective. Remote ischemic conditioning (RIC) is a cardioprotective method in ischemia/reperfusion (I/R) injury. This study investigated the mechanism of Rho-kinase-mediated autophagy in RIC. Methods.
Jie Gao, Feng Min, Shasha Wang, Heng Lv, Huan Liang, Ben Cai, Xianjie Jia, Qin Gao, Ying Yu   +8 more
doaj   +1 more source

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]

, 2020
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Ma, Jiao, Meng, Xiao-Wen, Peng, Ke, Song, Nan, Song, Shao-Yong, Wang, Hui, Zhang, Juan   +10 more
core   +1 more source