The protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage [PDF]
Brain and Behavior, 2022 Purpose: To investigate the role and mechanism of protein kinase R (PKR) in subarachnoid hemorrhage (SAH)‐mediated ferroptosis. Methods: A rat SAH model was constructed and treated with PKR inhibitor C16 to observe SAH and neurological impairment in rats
Jianwei Lei +5 more
doaj +2 more sources
The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration [PDF]
Frontiers in Aging Neuroscience, 2021 There is a growing evidence describing a decline in adaptive homeostasis in aging-related diseases affecting the central nervous system (CNS), many of which are characterized by the appearance of non-native protein aggregates.
Nicolás W. Martinez +8 more
doaj +2 more sources
Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy [PDF]
Frontiers in Microbiology, 2021 Tuberculosis (TB) is a deadly infectious lung disease caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb). The identification of macrophage signaling proteins exploited by Mtb during infection will enable the development of alternative ...
Robin Smyth +5 more
doaj +2 more sources
TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes [PDF]
Neurobiology of Disease, 2019 TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS).
Thomas J. LaRocca +3 more
doaj +2 more sources
The A150V Polymorphism of Genotype 3 Hepatitis C Virus Polymerase Inhibits Interferon Alfa by Suppressing Protein Kinase R Activation [PDF]
Cell Mol Gastroenterol Hepatol, 2020 Wing-Yiu Jason Lee +4 more
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Chandipura Virus Forms Cytoplasmic Inclusion Bodies through Phase Separation and Proviral Association of Cellular Protein Kinase R and Stress Granule Protein TIA-1 [PDF]
VirusesSharmistha Sarkar +4 more
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ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]
, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun +12 more
core +2 more sources
Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl [PDF]
, 1999 Cells from individuals with the recessive cancer-prone disorder ataxia telangiectasia (A-T) are hypersensitive to ionizing radiation (I-R). ATM (mutated in A-T) is a protein kinase whose activity is stimulated by I-R. c-Abl, a nonreceptor tyrosine kinase,
Arlinghaus, Ralph +14 more
core +1 more source
Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways
Asian Pacific Journal of Tropical Medicine, 2018 Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus (CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 ...
Swati Gupta +5 more
doaj +1 more source
Fisetin protects against streptozotocin-induced diabetic cardiomyopathy in rats by suppressing fatty acid oxidation and inhibiting protein kinase R [PDF]
Saudi Pharm J, 2020 Jozaa Z. AlTamimi +5 more
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