The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration [PDF]
Frontiers in Aging Neuroscience, 2021 There is a growing evidence describing a decline in adaptive homeostasis in aging-related diseases affecting the central nervous system (CNS), many of which are characterized by the appearance of non-native protein aggregates.
Nicolás W. Martinez +8 more
doaj +2 more sources
Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1 [PDF]
Journal of Virology, 2017 ABSTRACT Double-stranded RNAs (dsRNA) produced during human cytomegalovirus (HCMV) infection activate the antiviral kinase protein kinase R (PKR), which potently inhibits virus replication. The HCMV pTRS1 and pIRS1 proteins antagonize PKR to promote HCMV protein synthesis and replication; however, the mechanism by which pTRS1 ...
Heather A. Vincent +2 more
openalex +3 more sources
Fisetin protects against streptozotocin-induced diabetic cardiomyopathy in rats by suppressing fatty acid oxidation and inhibiting protein kinase R [PDF]
Saudi Pharmaceutical Journal, 2021 This study examined if the Fisetin against streptozotocin-induced diabetic cardiomyopathy (DC) in rats involves regulating cardiac metabolism and suppressing protein kinase R (PKR).
Jozaa Z. ALTamimi +5 more
doaj +2 more sources
Species Specificity of Protein Kinase R Antagonism by Cytomegalovirus TRS1 Genes [PDF]
Journal of Virology, 2012 ABSTRACT The host antiviral protein kinase R (PKR) has rapidly evolved during primate evolution, likely in response to challenges posed by many different viral antagonists, such as the TRS1 gene of cytomegaloviruses (CMVs). In turn, viral antagonists have adapted to changes in PKR.
Stephanie J. Child +3 more
openalex +4 more sources
Molecular Determinants of Species-Specific Interactions Between Protein Kinase R and Poxvirus K3 Orthologs [PDF]
VirusesProtein kinase R (PKR) is an antiviral protein that is involved in molecular “arms races” with viral antagonists. As a result, some PKR inhibitors, including the vaccinia virus (VACV) protein K3 and its orthologs from other poxviruses only inhibit PKRs ...
Chorong Park +6 more
doaj +2 more sources
Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion [PDF]
VirusesYaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Dewi Megawati +6 more
doaj +2 more sources
Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy [PDF]
Frontiers in Microbiology, 2021 Tuberculosis (TB) is a deadly infectious lung disease caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb). The identification of macrophage signaling proteins exploited by Mtb during infection will enable the development of alternative ...
Robin Smyth +5 more
doaj +2 more sources
Acute Pharmacological Inhibition of Protein Kinase R-Like Endoplasmic Reticulum Kinase Signaling After Spinal Cord Injury Spares Oligodendrocytes and Improves Locomotor Recovery. [PDF]
J Neurotrauma, 2023 Saraswat Ohri S +6 more
europepmc +3 more sources
Protein Kinase R Is Constitutively Expressed in the Human Pancreas. [PDF]
J Histochem Cytochem, 2019 Summary Viral infection of the insulin-producing cells in the pancreas has been proposed in the etiology of type 1 diabetes. Protein kinase R (PKR) is a cytoplasmic protein activated through phosphorylation in response to cellular stress and particularly viral infection.
Jonsson A +5 more
europepmc +4 more sources
Inhibition of protein kinase R suppresses HIV replication and integration in CD4 T cells [PDF]
Journal of Virus EradicationEvaluation of CD4 T cell status in early HIV infection is critical for developing strategies targeting HIV replication. In this study, we infected CD4 T cells with HIV-1 and investigated the cell survival mechanisms in HIV-infected versus uninfected ...
Jaeden Pyburn +14 more
doaj +2 more sources