Results 21 to 30 of about 1,314,106 (300)

Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis [PDF]

, 2016
An increase in intracellular calcium represents one of the early events during an ischaemic stroke. It triggers many downstream processes which promote the formation of brain oedema, the leading cause of death after an ischaemic stroke.
Abbruscato, Abdullah, Ahn, Allen, Allen, Allen, Alluri, Bohlen, Booth, Brouns, Brown, Chavakis, Cho, Christow, Cook-Mills, Cruzalegui, De Bock, Degraba, Eltzschig, Espinosa, Fibbi, Fischer, Fleegal, Fontayne, Garcia, Garcia, Gelmers, Gibson, Ginty, Gopalakrishna, Grotta, Gueler, Hacke, Hayashi, Hayashi, Hempel, Heo, Hixenbaugh, Holthoff, Hong, Horn, Hosomi, Hu, Hu, Inoguchi, Jia, Kamini Rakkar, Kaur, Kimura, Korthuis, Kouroedov, Lagrange, Langer, Lee, Lee, Lengyel, Liot, Lum, Mason, Matsumoto, Matthews, Mitra, Mohamed, Nakajima, Nicole, Nowycky, Oancea, Pan, Pandey, Park, Paschen, Persidsky, Raad, Rakkar, Rao, Rosenberg, Samson, Schreibelt, Seta, Shao, Shao, Sheth, Sims, Sitrin, Srivastava, Stuart, Tang, Thallas-Bonke, Tiruppathi, Ulvi Bayraktutan, Umemoto, van der Goes, Wang, Wiessner, Yang, Ye, Yepes, Zehendner, Zhang, Zhang   +99 more
core   +1 more source

A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists. [PDF]

PLoS Pathogens, 2016
During millions of years of coevolution with their hosts, cytomegaloviruses (CMVs) have succeeded in adapting to overcome host-specific immune defenses, including the protein kinase R (PKR) pathway.
Kathryn S Carpentier, Nicolle M Esparo, Stephanie J Child, Adam P Geballe   +3 more
doaj   +1 more source

RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules [PDF]

J Virol, 2020
Praveen Manivannan, Mohammad Adnan Siddiqui, Krishnamurthy Malathi   +2 more
openalex   +2 more sources

Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis. [PDF]

, 2018
Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, the biological role of
Feng, Pan, Gao, Erhe, Lau, Wayne Bond, Ma, Xin-Liang, Qin, Zhigang, Sun, Yang, Tan, Yanzhen, Xu, Xuezeng, Yang, Jian, Yi, Dinghua, Yi, Wei, Yu, Shiqiang, Zhang, Zhengbin, Zhao, Dajun   +13 more
core   +2 more sources

A Toll-Like Receptor-Responsive Kinase, Protein Kinase R, Is Inactivated in Endotoxin Tolerance through Differential K63/K48 Ubiquitination

mBio, 2010
Overwhelming inflammation triggered by systemic infection in bacterial sepsis contributes to the pathology of this condition. Toll-like receptors (TLRs) are important in early septic inflammation.
Darren J. Perkins, Nilofer Qureshi, Stefanie N. Vogel   +2 more
doaj   +1 more source

Chemotherapy‐Induced Senescence Reprogramming Promotes Nasopharyngeal Carcinoma Metastasis by circRNA‐Mediated PKR Activation

Advanced Science, 2023
Senescence is associated with tumor metastasis and chemotherapy resistance, yet the mechanisms remain elusive. Here, it is identified that nasopharyngeal carcinoma (NPC) patients who developed distant metastasis are characterized by senescence phenotypes,
Qian Li, Yu‐Heng Zhao, Cheng Xu, Ye‐Lin Liang, Yin Zhao, Qing‐Mei He, Jun‐Yan Li, Kai‐Lin Chen, Han Qiao, Na Liu, Jun Ma, Lei Chen, Ying‐Qin Li   +12 more
doaj   +1 more source

Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparumschizonts develop into extracellular invasive merozoites [PDF]

, 2015
Pathology of the most lethal form of malaria is caused by Plasmodium falciparum asexual blood stages and initiated by merozoite invasion of erythrocytes.
Grainger, Munira, Green, Judith L., Holder, Anthony A., Langsley, Gordon, Lasonder, Edwin   +4 more
core   +1 more source

Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. [PDF]

, 2020
Cyclin-dependent kinase 7 (CDK7) is a protein kinase that plays a major role in transcription initiation. Yes-associated protein (YAP) is a main effector of the Hippo/YAP signalling pathway.
Bin, Hu, Chan, Geraldine, Jablons, David M, Kyoyama, Hiroyuki, Li, Hui, Liu, Luwei, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Wang, Yucheng, Xu, Zhidong, Yang, Yi-Lin, You, Liang   +12 more
core  

Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I [PDF]

, 1995
We have analysed phosphorylation of the synthetic peptide AMARAASAAALARRR, and 23 variants, by mammalian, higher plant and yeast members of the SNF1 protein kinase subfamily (AMP-activated protein kinase (AMPK), HMG-CoA reductase kinase (HRK-A), and SNF1
Dale, Susan, Edelman, Arthur M., Hardie, D.Grahame, Wilson, Wayne A.   +3 more
core   +1 more source

ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C

Медицинская иммунология, 2014
. Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C.
V. A. Bychkov, N. V. Ryazantseva, V. V. Novitskiy, N. A. Semenova, L. A. Kleptsova, V. D. Yakushina   +5 more
doaj   +1 more source