TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes [PDF]
Neurobiology of Disease, 2019 TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS).
Thomas J. LaRocca +3 more
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Protein kinase R-like endoplasmic reticulum kinase pathway and diabetic kidney disease
Linchuang shenzangbing zazhi, 2020 Endoplasmic reticulum stress is closely related to the occurrence and development of diabetic kidney disease.As an important signaling pathway induced by endoplasmic reticulum stress,protein kinase R-like endoplasmic reticulum kinase(PERK)pathway can ...
庞欣欣 +5 more
doaj +1 more source
Protein kinase R-like endoplasmic reticulum kinase is a mediator of stretch in ventilator-induced lung injury [PDF]
Respiratory Research, 2018 Background Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure.
Tamás Dolinay +12 more
doaj +5 more sources
Role of protein kinase R in metabolic homeostasis
, 2017 Obesity related conditions, predominantly cardiovascular disease and diabetes constitute the most significant burden to healthcare in much of the western world. The physiological response to excess nutrients influences the health consequence of obesity. Hence regulation of cellular processes that maintain energy homeostasis, such as protein translation,
Agnieszka Pindel
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Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress [PDF]
Molecular and Cellular Biology, 2016 High extracellular osmolarity results in a switch from an adaptive to an inflammatory gene expression program. We show that hyperosmotic stress activates the protein kinase R (PKR) independently of its RNA-binding domain. In turn, PKR stimulates nuclear accumulation of nuclear factor κB (NF-κB) p65 species phosphorylated at serine-536, which is ...
Kenneth T. Farabaugh +14 more
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The A150V Polymorphism of Genotype 3 Hepatitis C Virus Polymerase Inhibits Interferon Alfa by Suppressing Protein Kinase R Activation. [PDF]
Cell Mol Gastroenterol Hepatol, 2021 Lee WJ +4 more
europepmc +3 more sources
Species-specific inhibition of capripoxvirus replication by host antiviral protein kinase R. [PDF]
Ann N Y Acad Sci, 2019 AbstractThe role of interferon (IFN)‐induced protein kinase R (PKR) in capripoxvirus (CaPV)‐infected cells remains unknown. In this study, we show that CaPV infection triggered PKR and eukaryotic translation initiation factor 2 alpha (eIF2α) protein phosphorylation in a dose‐dependent manner, and that this leads to decreased CaPV replication ...
Zhao Z +7 more
europepmc +4 more sources
Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus. [PDF]
J Virol, 2020 Beauclair G +11 more
europepmc +3 more sources
Roles of protein kinase R in cancer: Potential as a therapeutic target. [PDF]
Cancer Sci, 2018 Double‐stranded (ds) RNA‐dependent protein kinase (PKR) is a ubiquitously expressed serine/threonine protein kinase. It was initially identified as an innate immune antiviral protein induced by interferon (IFN) and activated by dsRNA. PKR is recognized as a key executor of antiviral host defense.
Watanabe T, Imamura T, Hiasa Y.
europepmc +4 more sources
Host WD repeat-containing protein 5 inhibits protein kinase R-mediated integrated stress response during measles virus infection. [PDF]
J VirolBenDavid E +5 more
europepmc +3 more sources