Confirming the importance of the R-spine: new insights into protein kinase regulation. [PDF]
PLoS Biology, 2013 Richard Robinson
doaj +3 more sources
Puumala and Andes Orthohantaviruses Cause Transient Protein Kinase R-Dependent Formation of Stress Granules. [PDF]
J Virol, 2020 Christ W, Tynell J, Klingström J.
europepmc +3 more sources
VHS, US3 and UL13 viral tegument proteins are required for Herpes Simplex Virus-Induced modification of protein kinase R. [PDF]
Sci Rep, 2020 Pennisi R +4 more
europepmc +3 more sources
Auto-phosphorylation Represses Protein Kinase R Activity [PDF]
Scientific Reports, 2017 AbstractThe central role of protein kinases in controlling disease processes has spurred efforts to develop pharmaceutical regulators of their activity. A rational strategy to achieve this end is to determine intrinsic auto-regulatory processes, then selectively target these different states of kinases to repress their activation.
Wang, D +5 more
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Dual Activators of Protein Kinase R (PKR) and Protein Kinase R‐Like Kinase (PERK) Identify Common and Divergent Catalytic Targets [PDF]
ChemBioChem, 2013 AbstractChemical genetics has evolved into a powerful tool for studying gene function in normal and pathobiology. PKR and PERK, two eukaryotic translation initiation factor 2 alpha (eIF2α) kinases, play critical roles in the maintenance of cellular hemostasis, metabolic stability, and anti‐viral defenses.
Huijun, Bai +9 more
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The protein activator of protein kinase R,
The FEBS Journal, 2015 The murine double‐stranded RNA‐binding protein termed protein kinase R (PKR)‐associated protein X (RAX) and the human homolog, protein activator of PKR (PACT), were originally characterized as activators of PKR. Mice deficient in RAX show reproductive and developmental defects, including reduced body size, craniofacial defects and anterior pituitary ...
Benjamin K, Dickerman +5 more
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Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]
, 2020 BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai +10 more
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Poultry Science, 2023 : This study aimed to investigate whether the developmental changes in glucose metabolism were associated with insulin signaling in the middle and later stages of goose embryos.
H. Wang +6 more
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Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis [PDF]
Nature Chemical Biology, 2013 Formation of the inflammasome, a scaffolding complex that activates caspase-1, is important in numerous diseases. Pyroptotic cell death induced by anthrax lethal toxin (LT) is a model for inflammasome-mediated caspase-1 activation. We discovered 7-desacetoxy-6,7-dehydrogedunin (7DG) in a phenotypic screen as a small molecule that protects macrophages ...
Hett, Erik C +7 more
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Cardiovascular Therapeutics, 2022 Objective. Remote ischemic conditioning (RIC) is a cardioprotective method in ischemia/reperfusion (I/R) injury. This study investigated the mechanism of Rho-kinase-mediated autophagy in RIC. Methods.
Jie Gao +8 more
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