Results 241 to 250 of about 3,403,581 (279)
Some of the next articles are maybe not open access.
2020
Protein folding is considered strongly linked with genetics. The deeper understanding of the mechanisms that allow the folding of proteins is expected to lead to advances in the pharmaceutical sector. The shape of a protein dictates its biological activity, and any exceptions from its natural form can lead to diseases such as Alzheimer's, Parkinson's ...
openaire +2 more sources
Protein folding is considered strongly linked with genetics. The deeper understanding of the mechanisms that allow the folding of proteins is expected to lead to advances in the pharmaceutical sector. The shape of a protein dictates its biological activity, and any exceptions from its natural form can lead to diseases such as Alzheimer's, Parkinson's ...
openaire +2 more sources
Protein degradation, aggregation, and misfolding
Movement Disorders, 2010AbstractThe cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular ...
Ana Maria, Cuervo +2 more
openaire +2 more sources
Protein misfolding and disease: the case of prion disorders [PDF]
Cellular and Molecular Life Sciences, 2003 Recent findings strongly support the hypothesis that diverse human disorders, including the most common neurodegenerative diseases, arise from misfolding and aggregation of an underlying protein.
Claudio Soto
exaly +2 more sources
Protein folding and misfolding
Nature, 2003The manner in which a newly synthesized chain of amino acids transforms itself into a perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence and on multiple contributing influences from the crowded cellular milieu.
openaire +2 more sources
Protein Misfolding and Human Disease
Annual Review of Genomics and Human Genetics, 2006Protein misfolding is a common event in living cells. In young and healthy cells, the misfolded protein load is disposed of by protein quality control (PQC) systems. In aging cells and in cells from certain individuals with genetic diseases, the load may overwhelm the PQC capacity, resulting in accumulation of misfolded proteins.
Niels, Gregersen +3 more
openaire +2 more sources
Principles of Protein Misfolding
2008Publisher Summary This chapter discusses the principles of protein misfolding. The process of incorrect folding is called “protein misfolding.” It is associated with a number of pathological states in humans, collectively termed “protein-misfolding diseases.” Among these protein-misfolding diseases, amyloid diseases are characterized by the presence ...
openaire +2 more sources
Protein misfolding in hemophilia
Over the past century, the development of advancements in hemophilia therapy has experienced unprecedented success, starting with virally contaminated blood product infusions and progressing to safe plasma-derived and recombinant factor replacements, non-factor based rebalancing agents, long-lasting gene therapies, and moving forward into an era of ...Bilgimol, Chumappumkal Joseph +4 more
openaire +2 more sources
Proteomics in protein misfolding diseases
Clinical Chemistry and Laboratory Medicine, 2009Protein misfolding and deposition as amyloid, with consequent tissue damage, plays a key role in the group of diseases generically termed amyloidoses. In the systemic forms, amyloid deposition is widespread and causes severe dysfunction of vital organs.
STOPPINI, MONICA +7 more
openaire +3 more sources
Mathematics of protein pathological misfolding
Mathematical Biosciences, 2007"Protein folding is defined as a process by which a polypeptide chain performs a search in conformational space with the objective of achieving the so-called native conformation to global free-energy minimum under a given set of physiochemical conditions of the medium." Misfolding then, is the process by which this objective is not achieved.
openaire +2 more sources
Autophagy and the Metabolism of Misfolding Protein
2019Autophagy is a major intracellular degradative process that delivers cytoplasmic materials to the lysosome for degradation. An increasing number of studies on the physiological and pathological roles of autophagy in a variety of autophagy knockout models and human diseases were carried out.
Chao, Cheng, Zhen-Guo, Liu
openaire +2 more sources