Results 251 to 260 of about 3,403,581 (279)

Protein Misfolding: Optional Barriers, Misfolded Intermediates, and Pathway Heterogeneity

Journal of Molecular Biology, 2004
To investigate the character and role of misfolded intermediates in protein folding, a recombinant cytochrome c without the normally blocking histidine to heme misligation was studied. Folding remains heterogeneous as in the wild-type protein. Half of the population folds relatively rapidly to the native state in a two-state manner.
Mallela M G, Krishna, Yan, Lin, S Walter, Englander   +2 more
openaire   +2 more sources

Trashing misfolded membrane proteins

Science, 2014
A branch of the endoplasmic reticulum–associated protein degradation system degrades inner nuclear membrane proteins in yeast.
openaire   +1 more source

Protein misfolding, evolution and disease

Trends in Biochemical Sciences, 1999
I acknowledge very valuable discussions on this article with John Ellis and Carol Robinson. I am grateful to Jose Jiminez and Helen Saibil for providing Figure 3Figure 3 and to Adam Rostom for producing Figure 1Figure 1. This paper is a contribution from the Oxford Centre for Molecular Sciences, which is funded by the BBSRC, EPSRC and MRC. The research
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The folding and misfolding of multidomain proteins

Molecular Aspects of Medicine
Protein folding represents a vital process for any living organism. While significant insights have been gained from studying single-domain proteins, our current knowledge on the folding mechanisms of multidomain proteins remains relatively limited, primarily due to their inherent complexity.
Stefano Gianni, Maurizio Brunori
openaire   +3 more sources

Modeling of Protein Misfolding in Disease

2008
A short review of the results of molecular modeling of prion disease is presented in this chapter. According to the "one-protein theory" proposed by Prusiner, prion proteins are misfolded naturally occurring proteins, which, on interaction with correctly folded proteins may induce misfolding and propagate the disease, resulting in insoluble amyloid ...
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Misfolded Proteins

2021
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Misfolded Proteins

ASA Monitor
Dibash Kumar Das, Steven L. Shafer
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Protein Misfolding

2017
Marie-Theres Hutchison, Harald Schwalbe
openaire   +1 more source

Protein Misfolding Diseases

Annual Review of Biochemistry, 2017
F Ulrich Hartl
exaly  

Type 2 diabetes as a protein misfolding disease

Trends in Molecular Medicine, 2015
Abhisek Mukherjee, Peter Butler, Claudio Soto   +2 more
exaly