Results 231 to 240 of about 3,647,798 (263)

Mathematics of protein pathological misfolding

Mathematical Biosciences, 2007
"Protein folding is defined as a process by which a polypeptide chain performs a search in conformational space with the objective of achieving the so-called native conformation to global free-energy minimum under a given set of physiochemical conditions of the medium." Misfolding then, is the process by which this objective is not achieved.
openaire   +2 more sources

Protein Misfolding: Optional Barriers, Misfolded Intermediates, and Pathway Heterogeneity

Journal of Molecular Biology, 2004
To investigate the character and role of misfolded intermediates in protein folding, a recombinant cytochrome c without the normally blocking histidine to heme misligation was studied. Folding remains heterogeneous as in the wild-type protein. Half of the population folds relatively rapidly to the native state in a two-state manner.
Mallela M G, Krishna, Yan, Lin, S Walter, Englander   +2 more
openaire   +2 more sources

Trashing misfolded membrane proteins

Science, 2014
A branch of the endoplasmic reticulum–associated protein degradation system degrades inner nuclear membrane proteins in yeast.
openaire   +1 more source

Modeling of Protein Misfolding in Disease

2008
A short review of the results of molecular modeling of prion disease is presented in this chapter. According to the "one-protein theory" proposed by Prusiner, prion proteins are misfolded naturally occurring proteins, which, on interaction with correctly folded proteins may induce misfolding and propagate the disease, resulting in insoluble amyloid ...
openaire   +2 more sources

Protein misfolding, evolution and disease

Trends in Biochemical Sciences, 1999
I acknowledge very valuable discussions on this article with John Ellis and Carol Robinson. I am grateful to Jose Jiminez and Helen Saibil for providing Figure 3Figure 3 and to Adam Rostom for producing Figure 1Figure 1. This paper is a contribution from the Oxford Centre for Molecular Sciences, which is funded by the BBSRC, EPSRC and MRC. The research
openaire   +2 more sources

The folding and misfolding of multidomain proteins

Molecular Aspects of Medicine
Protein folding represents a vital process for any living organism. While significant insights have been gained from studying single-domain proteins, our current knowledge on the folding mechanisms of multidomain proteins remains relatively limited, primarily due to their inherent complexity.
Stefano Gianni, Maurizio Brunori
openaire   +3 more sources

Mechanisms and Pathology of Protein Misfolding and Aggregation

Nature Reviews Molecular Cell Biology, 2023
Nikolaos N Louros, Frederic Rousseau, Joost Schymkowitz   +2 more
exaly  

Advanced Techniques for Detecting Protein Misfolding and Aggregation in Cellular Environments

Chemical Reviews, 2023
Xin Zhang, Yu Liu, Shengnan Zhang
exaly  

Misfolded Proteins

2021
openaire   +1 more source

Involvement of Molecular Chaperone in Protein-Misfolding Brain Diseases

Biomedicine and Pharmacotherapy, 2022
Mohammed Al-Bratty, Ahmed Al-Harrasi, Hafiz A Makeen   +2 more
exaly