Results 211 to 220 of about 3,403,581 (279)

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Screening of Anti-Prion Compounds Using the Protein Misfolding Cyclic Amplification Technology. [PDF]

Biomolecules
Pritzkow S, Schauer I, Tupaki-Sreepurna A, Morales R, Soto C.   +4 more
europepmc   +1 more source

Biofortification of Chlorella vulgaris With Selenium and Iron Microminerals and Investigation of Some Bioactive Compounds: A Promising Dietary Supplement

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study was designed to investigate the effects of varying concentrations of selenium and iron on the growth of Chlorella vulgaris microalgae and its potential for bioaccumulation of these essential micronutrients. The optimal concentration for each metal was determined through detailed assessment of growth parameters.
Masoumeh Rezaei Moshaei, Mohammad Azadbakht, Akbar Hajizadeh Moghaddam, Mahbobeh Ghanbarzadeh   +3 more
wiley   +1 more source

An adenine model of inborn metabolism errors alters TDP-43 aggregation and reduces its toxicity in yeast revealing insights into protein misfolding diseases. [PDF]

Microb Cell
Park S, Park SK, Blair P, Liebman SW.
europepmc   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Adaptation of the protein misfolding cyclic amplification (PMCA) technique for the screening of anti-prion compounds. [PDF]

FASEB J
Do K, Benavente R, Catumbela CSG, Khan U, Kramm C, Soto C, Morales R.   +6 more
europepmc   +1 more source

Neural Stem Cell‐Derived Extracellular Vesicles Improve CNS Delivery and Therapeutic Efficacy of Antisense Oligonucleotide in Amyotrophic Lateral Sclerosis

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Passive ASO association with NSC‐EVs enhances neuronal uptake and CNS accumulation. NSC‐EV‐ASOs suppress pathogenic targets in ALS cellular models and, following intranasal administration, delay disease onset and improve motor function in SOD1‐G93A mice. These findings provide proof‐of‐concept evidence supporting NSC‐EVs as a platform for enhancing CNS
Yaochao Zheng, Taylor Jade Ellison, Robert Garrard, Jinghui Gao, Xinning Lai, Lin Lan, Jin Xie, Jie Jiang, Yao Yao   +8 more
wiley   +1 more source

Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity. [PDF]

Neural Regen Res
Cembran A, Fernandez-Funez P.
europepmc   +1 more source