Results 191 to 200 of about 3,403,581 (279)

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

New Role of Protein Misfolding Corrector in the ER Stress-Inflammation Axis: Possible Therapeutic Indication in Neuronal and Epithelial Tumor Cells. [PDF]

Int J Mol Sci
Pecoraro M, Serra A, Lamberti MJ, Pascale M, Franceschelli S.   +4 more
europepmc   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, Volume 13, Issue 51, 14 September 2026.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Protein Misfolding and Aggregation as a Mechanistic Link Between Chronic Pain and Neurodegenerative Diseases. [PDF]

Curr Issues Mol Biol
Brezic N, Gligorevic S, Sic A, Knezevic NN.   +3 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Non-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles. [PDF]

Sci Adv
Vu QV, Sitarik I, Jiang Y, Xia Y, Sharma P, Yadav D, Song H, Li MS, Fried SD, O'Brien EP.   +9 more
europepmc   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Optimization of a High-Throughput Screen for Monitoring Disease-Associated Protein Misfolding and Aggregation in Bacteria. [PDF]

ACS Synth Biol
Delivoria DC, Konia E, Matis I, Skretas G.   +3 more
europepmc   +1 more source

Distinct single‐nucleus RNA‐seq changes among non‐neuronal cells in ADNC, LATE‐NC, and mixed pathologies

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA binding protein 43 kDa encephalopathy neuropathological change (LATE‐NC) frequently co‐occurs with Alzheimer's disease neuropathologic change (ADNC), complicating classification.
Qi Qiao, Yuriko Katsumata, Hsin‐Yu Lai, Kevin Z. Lin, Steven A. Claas, Mariano I. Gabitto, Josh M. Morganti, Peter T. Nelson, Shubhabrata Mukherjee, David W. Fardo   +9 more
wiley   +1 more source

Protein misfolding involving entanglements providesa structural explanation for the origin of stretched-exponential refolding kinetics. [PDF]

Sci Adv
Jiang Y, Xia Y, Sitarik I, Sharma P, Song H, Fried SD, O'Brien EP.   +6 more
europepmc   +1 more source