Results 181 to 190 of about 3,403,581 (279)

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation

Protein Science, Volume 35, Issue 10, October 2026.
Abstract In numerous neurodegenerative diseases known collectively as tauopathies, the microtubule‐associated protein tau forms fibrillar aggregates that are hallmarks of disease pathology. Tauopathies represent a substantial fraction of diseases associated with protein misfolding.
Mia Cervantes, Maria K. Janowska, Lisa M. Tuttle, Miklos Guttman, Abhinav Nath, Rachel E. Klevit   +5 more
wiley   +1 more source

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1717-1737, October 2026.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

From Protein Misfolding to Extracellular Matrix Disorganisation: Understanding Disease Pathology in Rare Skeletal Dysplasias. [PDF]

Int J Mol Sci
Dennis EP, Briggs MD.
europepmc   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

Metal-Responsive Up-Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding. [PDF]

Angew Chem Int Ed Engl
Mori K, Kuramochi T, Matsusaki M, Hashiguchi Y, Okumura M, Saio T, Furukawa Y, Arai K, Muraoka T.   +8 more
europepmc   +1 more source

De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Genetically encoded cyclic peptide libraries can be employed in cellular selection platforms to identify cyclic peptide inhibitors for therapeutic targets by directly selecting for desired biological activities. This review systematically summarizes representative studies and suggests future opportunities for using cellular selection for de novo cyclic
Linwei Yang, Abhijit Behera, Hannah J. Meyers, Tina Wang   +3 more
wiley   +1 more source

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Jiabin Duan, Jiaqi Liu, Qingsheng Meng, Jiahao Liu, Sitian Yang, Fang Zhou, Jing Cao   +6 more
wiley   +1 more source

Protein misfolding: understanding biology to classify and treat synucleinopathies. [PDF]

J Neural Transm (Vienna)
Outeiro TF, Höglinger G, Lang AE, Vieira TCRG.   +3 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, Volume 16, Issue 9, Page 1669-1690, September 2026.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Skin biopsy: an emerging tool for the diagnosis of protein misfolding diseases of the central nervous system. [PDF]

Mol Neurodegener
Zhu W, Sun HL, Wang YJ, Lei X, Bu XL.
europepmc   +1 more source