Results 201 to 210 of about 3,403,581 (279)

Rethinking tau‐targeted therapy in Alzheimer's disease: Toward a dual biomarker strategy

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Tau pathology is more closely associated with cognitive deterioration than amyloid burden in symptomatic Alzheimer's disease (AD), yet tau‐targeted trials have often interpreted decreases in soluble phosphorylated tau (p‐tau) as evidence of therapeutic success. Emerging data argue for a more biology‐informed framework.
Charlotte E. Teunissen, Lorenzo Pini, Bruno P. Imbimbo   +2 more
wiley   +1 more source

Cancers adapt to their mutational load by buffering protein misfolding stress. [PDF]

Elife
Tilk S, Frydman J, Curtis C, Petrov DA.
europepmc   +1 more source

Therapeutic Potential of Oxiracetam in Neurocognitive Disorders: A Narrative Review

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Purpose: Cognitive impairment is a growing global health concern associated with aging, neurodegenerative diseases, stroke, and traumatic brain injury. Existing pharmacological treatments, including cholinesterase inhibitors and memantine, provide limited and variable benefits.
Hafsa Ali, Syeda Maliha, Sundas Ishtiaq, Omer Al‐Karawi, Mohammed Hammad Jaber Amin   +4 more
wiley   +1 more source

Targeting Protein Misfolding and Aggregation as a Therapeutic Perspective in Neurodegenerative Disorders. [PDF]

Int J Mol Sci
Sidoryk-Węgrzynowicz M, Adamiak K, Strużyńska L.   +2 more
europepmc   +1 more source

Antiglycation and Amyloid‐β Inhibitory Activities of Pandanus odorifer Extracts and Isolated Constituents: In Vitro and Molecular Docking Insights

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Pandanus odorifer methanolic extract exhibited strong antiglycation activity, moderate antioxidant capacity, and high flavonoid content. Three isolated compounds reduced Aβ‐associated ThT fluorescence, with blumenol C glucoside showing the greatest effect.
Patricia Marie P. Oliva, Sarleen G. Castro, Joe Anthony H. Manzano, Hayato Ishikawa, Mario A. Tan   +4 more
wiley   +1 more source

Retraction Note: Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells. [PDF]

Sci Rep
Hara H, Chida J, Uchiyama K, Pasiana AD, Takahashi E, Kido H, Sakaguchi S.   +6 more
europepmc   +1 more source

Moringa oleifera Lam. Seed Lectin (WSMoL) Attenuates Parkinsonian Symptoms in Mice via Anti‐Inflammatory, Antioxidant, and Neurotransmitter‐Modulating Effects

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
WSMoL attenuates motor impairment, neuroinflammation, oxidative stress, and monoamine depletion in a rotenone‐induced model of Parkinson's disease. The involvement of D1 receptor‐mediated signaling is demonstrated, providing new insights into the mechanisms underlying its neuroprotective effects and supporting WSMoL as a promising candidate for further
Leydianne Leite de Siqueira Patriota, Emanuel Davi Lima de Matos Leão, Maria Nívea Bezerra da Silva, Amanda de Oliveira Marinho, Bárbara Raíssa Ferreira de Lima, Jainaldo Alves da Costa, Luciclaudio Cassimiro de Amorim, Valéria Bianca de Souza Santos, Patrícia Maria Guedes Paiva, Michelly Cristiny Pereira, Daniella Carla Napoleão, Jorge Vinícius Fernandes Lima Cavalcanti, Leucio Duarte Vieira, Michelle Melgarejo da Rosa, Thiago Henrique Napoleão   +14 more
wiley   +1 more source

Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8. [PDF]

Biomolecules
Yang Y, Peng H, Meng D, Fa Z, Yao C, Lin X, Schick J, Jin X.   +7 more
europepmc   +1 more source

Chronic Paraquat Neurotoxicity and Dopaminergic Degeneration: A Mechanistic Review

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Occurrence of Parkinson's disease (PD) based on several neurotoxins. Advanced and comprehensive mechanisms based on Paraquat‐induced PD. Mechanism of oxidative stress, ROS and RNS formation, and death of dopaminergic neurons. The modulation of genes and proteins by paraquat leads to Parkinsonism.
Saima Riaz, Shaukat Ali, Muhammad Summer, Amina Iqbal, Rimsha Ashraf, Ramzana Bibi   +5 more
wiley   +1 more source

The Unfolding Story of Protein Misfolding Causing Alzheimer Disease in Recipients of Human Pituitary Growth Hormone. [PDF]

J Endocr Soc
Graber EG, Hosseini SMH, Wilson DM, Rogol AD.   +3 more
europepmc   +1 more source