Results 221 to 230 of about 3,403,581 (279)

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source

Protein Misfolding in Pregnancy: Current Insights, Potential Mechanisms, and Implications for the Pathogenesis of Preeclampsia. [PDF]

Molecules
Medegan Fagla B, Buhimschi IA.
europepmc   +1 more source

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2081-2092, September 2026.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions. [PDF]

Nat Commun
Eraña H, Sampedro-Torres-Quevedo C, Charco JM, Díaz-Domínguez CM, Peccati F, San-Juan-Ansoleaga M, Vidal E, Gonçalves-Anjo N, Pérez-Castro MA, González-Miranda E, Piñeiro P, Fernández-Veiga L, Galarza-Ahumada J, Fernández-Muñoz E, Perez de Nanclares G, Telling G, Geijo M, Jiménez-Osés G, Castilla J.   +18 more
europepmc   +1 more source

A Perspective on Interdicting in Protein Misfolding for Therapeutic Drug Design: Modulating the Formation of Nonlocal Contacts in α-Synuclein as a Strategy against Parkinson's Disease. [PDF]

J Phys Chem B
Bergasa-Caceres F, Rabitz HA.
europepmc   +1 more source

Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort. [PDF]

Transl Neurodegener
Bigi A, Fani G, Bessi V, Napolitano L, Bagnoli S, Ingannato A, Neri L, Cascella R, Matteini P, Sorbi S, Nacmias B, Cecchi C, Chiti F.   +12 more
europepmc   +1 more source

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases. [PDF]

Mol Neurodegener
Rinauro DJ, Chiti F, Vendruscolo M, Limbocker R.   +3 more
europepmc   +1 more source