Results 81 to 90 of about 92,071 (194)

The different axes of the mammalian mitochondrial unfolded protein response

BMC Biology, 2018
Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs). Of particular recent interest has been the mitochondrial unfolded protein response (UPRmt), activated to restore protein
Christian Münch
doaj   +1 more source

Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers. [PDF]

, 2020
Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene.
de Oliveira, Guilherme AP, Ferretti, Giulia DS, Gratton, Enrico, Lima, Flavia RS, Motta, Michelle F, Norberto, Douglas R, Pedrote, Murilo M, Silva, Jerson L, Spohr, Tania CLS   +8 more
core   +1 more source

Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular Function

Frontiers in Molecular Neuroscience, 2017
Heat shock proteins (Hsps) are ubiquitously expressed chaperone proteins that enable cells to cope with environmental stresses that cause misfolding and denaturation of proteins.
Bernadett Kalmar, Linda Greensmith, Linda Greensmith   +2 more
doaj   +1 more source

Effects of confinement and crowding on folding of model proteins

, 2008
We perform molecular dynamics simulations for a simple coarse-grained model of crambin placed inside of a softly repulsive sphere of radius R. The confinement makes folding at the optimal temperature slower and affects the folding scenarios, but both ...
Baruah, Baukmketner, Cheung, Cieplak, Cieplak, Cieplak, Duroux, Ellis, Go, Hartl, Hoang, Honeycutt, Jewett, Kwiecinska, Luisi, M. Wojciechowski, Marek Cieplak, Matzke, Melo, Moilanen, Murtas, Rathore, Sulkowska, Sulkowska, Szymczak, Szymczak, Takagi   +26 more
core   +1 more source

Integrity of H1 helix in prion protein revealed by molecular dynamic simulations to be especially vulnerable to changes in the relative orientation of H1 and its S1 flank

, 2009
In the template-assistance model, normal prion protein (PrPC), the pathogenic cause of prion diseases such as Creutzfeldt-Jakob (CJD) in human, Bovine Spongiform Encephalopathy (BSE) in cow, and scrapie in sheep, converts to infectious prion (PrPSc ...
A Aguzzi, A Aguzzi, A Barducci, A Onufriev, C Guilbert, Chih-Yuan Tseng, Chun-Ping Yu, DA Case, DA Harris, E Lindahl, E Malolepsza, F Eghiaian, GJ Sharman, GS Jackson, H. C. Lee, HJC Berendsen, J Castilla, J Watzlawik, J Ziegler, JP Ryckaert, KM Pan, L Calzolai, M Horiuchi, ML DeMarco, ML DeMarco, MP Morrissey, N Guex, P Derreumaux, P Tompa, R Riek, RI Dima, S Megy, S Santini, S Santini, SA Kozin, SB Prusiner, T Muramoto, W Kabsch, WQ Zou, Y Levy, Y Levy   +40 more
core   +1 more source

Disulfide Bonding in Neurodegenerative Misfolding Diseases

International Journal of Cell Biology, 2013
In recent years an increasing number of neurodegenerative diseases has been linked to the misfolding of a specific protein and its subsequent accumulation into aggregated species, often toxic to the cell.
Maria Francesca Mossuto
doaj   +1 more source

Plant-Derived Nanomaterials and Protein Misfolding Disorders: Green Production Approaches, Biological Interactions, and Research Trends (2015–2025)

Applied Sciences
Protein misfolding and aggregation represent key pathological mechanisms in neurodegenerative and systemic amyloid disorders, yet disease-modifying therapeutic strategies remain limited.
Corina Dalia Toderescu, Iulia Cresneac, Alexandru Oancea, Svetlana Trifunschi, Melania Florina Munteanu, Casiana Boru   +5 more
doaj   +1 more source

Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration

Frontiers in Neurology, 2013
There are a vast number of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), associated with the rearrangement of specific proteins to non-native conformations that promotes ...
Kathleen A Burke, Elizabeth A Yates, Justin eLegleiter   +2 more
doaj   +1 more source

Error-proof programmable self-assembly of DNA-nanoparticle clusters

, 2007
We study theoretically a new generic scheme of programmable self-assembly of nanoparticles into clusters of desired geometry. The problem is motivated by the feasibility of highly selective DNA-mediated interactions between colloidal particles.
A. Y. Grosberg, Alexei V. Tkachenko, Nicholas A. Licata, P. de Gennes, R. A. L. Jones   +4 more
core   +1 more source

The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins

Biochemistry and Biophysics Reports
Signal peptides are a sequence of peptides located at the N-terminus of proteins and determine the protein secretion pathway and their destinations. The N-region is positively charged and influences the orientation of translocation.
Natalie G. Horgan, Anabela Djurovic-Topalovic, Taiwo A. Ademoye, Jessica S. Fortin   +3 more
doaj   +1 more source