Results 91 to 100 of about 1,139,517 (313)

Reactive sulfur species as emerging immunomodulators: mechanistic insights and therapeutic prospects

Frontiers in Immunology
Inflammation is a vital component of host defense and tissue repair, but its dysregulation contributes to chronic metabolic and immune-mediated diseases.
Youbang Chen, Ruiying Ji, Yixing Wu, Xiang Li, Hui Zhang, Chun-tao Yang   +5 more
doaj   +1 more source

Role of SUMO-1 modification in transcriptional activation

, 2012
In unstimulated cells, the transcription factor NF-κB is held in the cytoplasm in an inactive state by IκB inhibitor proteins. Activation of NF--KB is mediated by signal induced degradation of IκBα via the ubiquitin proteasome-dependent pathway ...
Pinto Desterro, Maria Joana
core  

Post-translational modification and regulation of human Spir protein

, 2011
Spir proteins are the primodial members of the emerging group of actin nucleation factors, which initiate actin polymerization by binding monomeric actin to one or multiple Wiskott-Aldrich Syndrome protein (WASp) homology-2 domains.
Lakshmi, Sreeja
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Inhibition of ABI2 ubiquitination-dependent degradation suppresses TNBC cell growth via down-regulating PI3K/Akt signaling pathway

Cancer Cell International
Triple negative breast cancer (TNBC) is a type of cancer that lacks receptor expression and has complex molecular mechanisms. Recent evidence shows that the ubiquitin-protease system is closely related to TNBC.
Linlin Lv, Shujing Li, Jie Kang, Yulin Li, Nannan Zhao, Dongman Ye, Fengying Qin, Jing Sun, Tao Yu, Huijian Wu   +9 more
doaj   +1 more source

-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease

, 2019
Post-translational modifications (PTMs) of proteins are becoming the focus of intense research due to their implications in a broad spectrum of neurodegenerative diseases.
George D. Mellick, Philip Ryan, Mingming Xu, Jonathan J. Danon, Ryan, Philip, Mellick, George D, Andrew K. Davey, Kassiou, Michael, Michael Kassiou, Danon, Jonathan J, Santosh Rudrawar, Xu, Mingming, Davey, Andrew K, Rudrawar, Santosh   +13 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Large scale clustering of protein sequences with FORCE - a layout based heuristic for weighted cluster editing

, 2007
Wittkop T, Baumbach J, Lobo FP, Rahmann S. Large scale clustering of protein sequences with FORCE - a layout based heuristic for weighted cluster editing. BMC Bioinformatics.
Wittkop, Tobias, Tobias Wittkop, Baumbach Jan, Lobo Francisco P, Sven Rahmann, Francisco P Lobo, Rahmann Sven, Jan Baumbach, Baumbach, Jan, Wittkop Tobias, Lobo, Francisco P., Rahmann, Sven   +11 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Studies of surface modification of polymers via photo-initiated grafting [PDF]

, 1990
Industrial biosynthesis of proteins used in medical therapy involves filtration through polymeric membranes in order to separate them from fermentation mixtures.
Preston, Linda Margaret
core