Results 81 to 90 of about 1,139,517 (313)
Chemically stabilized subtilisins in peptide synthesis [PDF]
, 2008 We have stabilized alcalaseTM and subtilisin Carlsberg (SC) against heat by chemical modification with ethylene glycol bis-succinimidyl succinate (EGNHS), a procedure not previously reported for subtilisins.
Ó Fágáin, Ciarán, Colleary, Sandra
core
Histochemical evaluation of protein oxidative modification in fibrinoid of the placenta, depending on calcium deposits, combined with iron deficiency anemia of pregnancy [PDF]
, 2018 Introduction. Both calcium and iron significantly affect the level of free radical processes. The aim of the study was to determine the levels of protein oxidative modification in fibrinoid of placenta of different localization areas, depending on the ...
Andrii I. POPOVYCH +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in EndocrinologyObjectiveDiabetic retinopathy (DR) is a leading cause of vision loss in diabetes, yet its underlying molecular drivers remain poorly defined. This study aimed to identify diabetic stress-responsive targets and explore the therapeutic potential of the ...
Kexin Li +8 more
doaj +1 more source
Development of methodologies for electrochemical protein modification
The chemical modification of proteins has significantly expanded the toolkit for numerous studies in chemical biology. Focusing on sustainability, electrochemistry has rapidly grown in protein modification over the past five years, albeit still in its ...
Chen, Xuanxiao
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Cell Death and DiseaseGATA-binding protein 4 (GATA4) is recognized for its significant roles in embryogenesis and various cancers. Through bioinformatics and clinical data, it appears that GATA4 plays a role in breast cancer development. Yet, the specific roles and mechanisms
Yuxi Yang +11 more
doaj +1 more source
PGRP-SC–mediated innate immune memory against pathogenic bacteria in Drosophila
hLifeTrained immunity is essential for innate immune cells to retain a memory of previously encountered pathogens, strengthening the hosts’ response against these pathogens. However, the mechanisms governing trained immunity have not been well elucidated.
Zihao Deng +9 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Scientific ReportsHepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, notoriously refractory to conventional chemotherapy. Historically, sulfane sulfur-based compounds have been explored for the treatment of HCC, but their efficacy has been ...
Xue Zheng +14 more
doaj +1 more source