Results 131 to 140 of about 30,111 (219)

Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis

Nature Communications
S-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on
Bin Huang, Hui Wang, Shuo Liu, Meng Hao, Dan Luo, Yi Zhou, Ying Huang, Yong Nian, Lei Zhang, Bo Chu, Chengqian Yin   +10 more
doaj   +1 more source

Protein S-palmitoylation regulates the virulence of plant pathogenic fungi

mBio
Protein S-palmitoylation, a universal posttranslational modification catalyzed by a specific group of palmitoyltransferases, plays crucial roles in diverse biological processes across organisms by modulating protein functions.
Mengmeng Guo, Leeza Tariq, Fengming Song
doaj   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

S-palmitoylation of MAP kinase is essential for fungal virulence

mBio
S-palmitoylation is an important reversible protein post-translational modification in organisms. However, its role in fungi is uncertain. Here, we found the treatment of the rice false fungus Ustilaginoidea virens with S-palmitoylation inhibitor 2 BP ...
Yuhang Duan, Pingping Li, Deyao Zhang, Lili Wang, Yuan Fang, Hong Hu, Qiulu Mao, Xiaolan Zhou, Panpan Zhao, Xuechun Li, Jinfeng Wei, Jintian Tang, Li Pan, Hao Liu, Xiaolin Chen, Xiaoyang Chen, Tom Hsiang, Junbin Huang, Lu Zheng   +18 more
doaj   +1 more source

Advances of Protein Palmitoylation in Tumor Cell Deaths. [PDF]

Cancers (Basel), 2023
Lin X, Shi Y, Zhan Y, Xing Y, Li Y, Zhou Z, Chen G.   +6 more
europepmc   +1 more source

Engineered depalmitoylases enable selective manipulation of protein localization and function

Nature Communications
S-Palmitoylation is a reversible post-translational modification that tunes the localization, stability, and function of an impressive array of proteins including ion channels, G-proteins, and synaptic proteins.
Srinidhi Jayaraman, Audrey Kochiss, Thy-Lan Alcalay, Pedro J. del Rivero Morfin, Manu Ben-Johny   +4 more
doaj   +1 more source

Feiyiliu mixture promotes non-small cell lung cancer cells apoptosis via inhibits ZDHHC18-mediated AKT1 phosphorylation

Heliyon
Protein post-translational modification (PTM) is a molecular switch that determines protein diversification and regulates cellular functions, affecting proteins' subcellular localization and three-dimensional structure.
Yuxia Liu, Liang Ding, Shitao Li, Lisha Li, Daijun Xing, Xin Zheng, Baochen Zhou   +6 more
doaj   +1 more source

Regulation of Cell Polarity by Posttranslational Protein Palmitoylation. [PDF]

Methods Mol Biol, 2022
Chen B, Guarino C, Azzi A, Erb H, Wu X.
europepmc   +1 more source