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Discovery of protein-palmitoylating enzymes
Pflügers Archiv - European Journal of Physiology, 2008Posttranslational modification provides proteins with additional function and regulatory control beyond genomic information, allowing cells to maintain homeostasis and respond to extracellular signals. Protein palmitoylation, the common posttranslational modification with the lipid palmitate, plays a pivotal role in protein trafficking and function ...
Ryouhei, Tsutsumi +2 more
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Methodology for Detecting Protein Palmitoylation
2020It is well established that palmitoylation plays a key role in the regulation of immune checkpoints, but the technical challenges in detecting protein palmitoylation have significantly prohibited further researches in this field. Till now, different approaches have been proposed, such as mutagenesis, antibody-based methods, bioinformatic prediction ...
Haojie, Lu, Caiyun, Fang
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Palmitoylation of brain capillary proteins
The International Journal of Biochemistry & Cell Biology, 1995Palmitoylation is a reversible posttranslational modification which is involved in the regulation of several membrane proteins such as beta 2-adrenergic receptor, p21ras and trimeric G-protein alpha-subunits. This covalent modification could be involved in the regulation of the numerous membrane proteins present in the blood-brain barrier capillaries ...
J F, Poulio, R, Béliveau
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Analysis of RGS Protein Palmitoylation
2003Palmitoylation refers to the covalent attachment of a 16-carbon fatty acid to cysteine residues of proteins. This modification occurs on many intracellular signaling proteins including regulators of G protein signaling proteins (RGS). Palmitoylation mediates the interaction of proteins with membranes and other proteins and can control the biological ...
Leah S, Bernstein +2 more
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Palmitoylation of proteins in cancer
Biochemical Society Transactions, 2017Post-translational modification of proteins by attachment of palmitate serves as a mechanism to regulate protein localization and function in both normal and malignant cells. Given the essential role that palmitoylation plays in cancer cell signaling, approaches that target palmitoylated proteins and palmitoyl acyltransferases (PATs) have the potential
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Reversible palmitoylation of signaling proteins
Current Opinion in Cell Biology, 1997Palmitoylation is unique among lipid modifications of proteins in that it is reversible and regulable. Recent advances in the study of palmitoylation include the following: the correlation of this modification with the localization of a signaling protein to specific membrane subdomains; the demonstration of a specific protein-protein interaction that ...
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Palmitoylation: policing protein stability and traffic
Nature Reviews Molecular Cell Biology, 2007Palmitate modifies both peripheral and integral membrane proteins and its addition can be permanent or transient, which makes it unique among the lipid modifications of proteins. The presence of palmitate on a protein affects how the protein interacts with lipids and proteins in a membrane compartment, and the reversibility of palmitoylation allows ...
Maurine E, Linder, Robert J, Deschenes
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Protein Modifications | Protein Palmitoylation
2021Robert. J. Deschenes, Justin J. Miller
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Mechanisms, regulation and functions of the unfolded protein response
Nature Reviews Molecular Cell Biology, 2020Claudio Hetz +2 more
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