Results 81 to 90 of about 17,355 (136)

S-palmitoylation of MAP kinase is essential for fungal virulence

mBio
S-palmitoylation is an important reversible protein post-translational modification in organisms. However, its role in fungi is uncertain. Here, we found the treatment of the rice false fungus Ustilaginoidea virens with S-palmitoylation inhibitor 2 BP ...
Yuhang Duan, Pingping Li, Deyao Zhang, Lili Wang, Yuan Fang, Hong Hu, Qiulu Mao, Xiaolan Zhou, Panpan Zhao, Xuechun Li, Jinfeng Wei, Jintian Tang, Li Pan, Hao Liu, Xiaolin Chen, Xiaoyang Chen, Tom Hsiang, Junbin Huang, Lu Zheng   +18 more
doaj   +1 more source

Advances of Protein Palmitoylation in Tumor Cell Deaths. [PDF]

Cancers (Basel), 2023
Lin X, Shi Y, Zhan Y, Xing Y, Li Y, Zhou Z, Chen G.   +6 more
europepmc   +1 more source

Engineered depalmitoylases enable selective manipulation of protein localization and function

Nature Communications
S-Palmitoylation is a reversible post-translational modification that tunes the localization, stability, and function of an impressive array of proteins including ion channels, G-proteins, and synaptic proteins.
Srinidhi Jayaraman, Audrey Kochiss, Thy-Lan Alcalay, Pedro J. del Rivero Morfin, Manu Ben-Johny   +4 more
doaj   +1 more source

Feiyiliu mixture promotes non-small cell lung cancer cells apoptosis via inhibits ZDHHC18-mediated AKT1 phosphorylation

Heliyon
Protein post-translational modification (PTM) is a molecular switch that determines protein diversification and regulates cellular functions, affecting proteins' subcellular localization and three-dimensional structure.
Yuxia Liu, Liang Ding, Shitao Li, Lisha Li, Daijun Xing, Xin Zheng, Baochen Zhou   +6 more
doaj   +1 more source

Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart

Cellular and Molecular Life Sciences
Excessive accumulation of long-chain fatty acids (LCFAs) in cardiomyocytes leads to cardiac lipid-induced insulin resistance (CLIR), impairing insulin signaling and glucose uptake.
Francesco Schianchi, Jeroen Guns, Freek G. Bouwman, Jeroen F.J. Bogie, Miranda Nabben, Agnieszka Strzelecka, Rick van Leeuwen, Dimitris Kapsokalyvas, Kaitlyn M.J.H. Dennis, Lisa C. Heather, Shujin Wang, Jan F.C. Glatz, Dietbert Neumann, Joost J.F.P. Luiken   +13 more
doaj   +1 more source

Regulation of Cell Polarity by Posttranslational Protein Palmitoylation. [PDF]

Methods Mol Biol, 2022
Chen B, Guarino C, Azzi A, Erb H, Wu X.
europepmc   +1 more source

Protein Palmitoylation in Bovine Ovarian Follicle. [PDF]

Int J Mol Sci, 2021
Uzbekova S, Teixeira-Gomes AP, Marestaing A, Jarrier-Gaillard P, Papillier P, Shedova EN, Singina GN, Uzbekov R, Labas V.   +8 more
europepmc   +1 more source

ZDHHC11-mediated palmitoylation of viral envelope protein restricts dengue virus replication: implication for the development of universal anti-flavivirus therapeutic strategies

Virology Journal
Palmitoylation is a key post-translational modification regulating viral replication, yet its regulatory mechanism in Dengue virus (DENV) infection remains elusive.
Mingshuang Lai, Lexin Zhang, Rongji Lai, Qin Du, Shilin Li, Jinsheng Liu, Baoren He, Bin Li, Limin Chen   +8 more
doaj   +1 more source

Protein palmitoylation regulates extracellular vesicle production and function in sepsis. [PDF]

J Extracell Biol, 2022
Yang X, Zheng E, Chatterjee V, Ma Y, Reynolds A, Villalba N, Wu MH, Yuan SY.   +7 more
europepmc   +1 more source

Palmitoylation-dependent regulation of innate and adaptive immunity: molecular insights and translational opportunities

Cellular & Molecular Biology Letters
Immune cells orchestrate organismal defense through pathogen surveillance, tissue homeostasis, and immune tolerance, with innate and adaptive subsets coordinating context-specific responses.
Binhui Zhou, Bowen Zhang, Yingcheng Qi, Sainan Li, Tingting Liu, Tong Li, Ying Wang, Haifeng Wang, Jiaqi Lu, Fei Cao, Xiaohong Kang, Eryan Kong, Yinming Liang   +12 more
doaj   +1 more source