Results 71 to 80 of about 3,365,420 (200)
Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8*[S]
Journal of Lipid Research, 2009 Palmitoylation is a posttranslational modification that regulates protein trafficking and stability. In this study we investigated whether the endosomal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) proteins syntaxin 7 ...
Yuhong He, Maurine E. Linder
doaj +1 more source
Analysis of protein palmitoylation in adipocytes [PDF]
, 2014 Blood glucose homeostasis is highly regulated and is essential for survival. A key process is the insulin-stimulated recruitment of the facilitative glucose transporter GLUT4 to the plasma membrane in adipocytes and muscle cells; defects in this pathway ...
Werno, Martin W.
core +2 more sources
The Drosophila protein palmitoylome: Characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases [PDF]
Fly, 2008 Palmitoylation is the post-translational addition of a palmitate moiety to a cysteine residue through a covalent thioester bond. The addition and removal of this modification is controlled by both palmitoyl acyl-transferases and thioesterases. Using bioinformatic analysis, we identified 22 DHHC family palmitoyl acyl-transferase homologs in the ...
Barbra A, Bannan +11 more
openaire +2 more sources
Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity
Cellular and Molecular Life SciencesBackground Synaptic plasticity, a fundamental process underlying learning and memory, depends on activity-driven changes in neural connectivity. S-palmitoylation, a reversible post-translational lipid modification, modulates synaptic protein function by ...
Agata Pytyś +15 more
doaj +1 more source
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
Insulin regulates lymphatic endothelial integrity via palmitoylation
Journal of Lipid ResearchLipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated with loss of lymphatic vessel integrity, which compromises organ function, protective immunity, and ...
Silvia Gonzalez-Nieves +10 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider +3 more
wiley +1 more source
Identification of Yeast Protein Sequences With Similarity to the ESCRT‐III Protein Snf7
Yeast, EarlyView.ABSTRACT Endosomal sorting complex required for transport (ESCRT‐III) is a membrane remodeling complex involved in a large number of cellular processes. It appears to perform an essential function in eukaryotes, since to date no eukaryotic organism completely devoid of ESCRT‐III has been found.
Thomas Brune, Ralf Kölling
wiley +1 more source
Understanding the Functional Role of Protein Palmitoylation in Disease [PDF]
, 2021 Protein S-palmitoylation is an essential post-translational modification that regulates protein structure and function. It consists of the attachment of a palmitic acid to one or more cysteine residues through a thioester linkage. In cellular proteins, S-
Vora, Hetika
core +1 more source
Medicine PlusProtein palmitoylation modification is a key lipidated post-translational modification that dynamically regulates protein function, subcellular localization, and signaling pathways in eukaryotic cells, with important implications for the onset and ...
Zhenteng Liu +5 more
doaj +1 more source