Protein phosphatase 2A dysfunction in Alzheimer’s disease [PDF]
Frontiers in Molecular Neuroscience, 2014 Protein Phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular processes, sophisticated regulatory mechanisms are ultimately ...
Jean-Marie eSontag, Estelle eSontag
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PROTEIN PHOSPHATASE 2A (PP2A) AS A THERAPEUTIC TARGET IN ACUTE MYELOID LEUKEMIA [PDF]
Frontiers in Oncology, 2016 Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic progenitor cells in which several genetic and epigenetic aberrations have been described.
Elena eArriazu +2 more
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Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases [PDF]
Medicina, 2023 New disease targets and medicinal chemistry approaches are urgently needed to develop novel therapeutic strategies for treating pulmonary diseases.
Howard Yu +8 more
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Protein Phosphatase 2A: Role in T Cells and Diseases [PDF]
Journal of Immunology Research, 2023 Protein phosphatase 2A (PP2A) is a serine–threonine phosphatase that plays an important role in the regulation of cell proliferation and signal transduction.
Suyasha Roy, Lalit Batra
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Nature Communications, 2021 Microsatellite instability (MSI), caused by deficiency of the DNA mismatch repair system, has been associated with improved response to immune checkpoint blockade (ICB).
Yu-Ting Yen +9 more
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PLoS ONE, 2015 Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways.
Ryotaro Yabe +6 more
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Protein Phosphatase 2A Mediates Oxidative Stress Induced Apoptosis in Osteoblasts
Mediators of Inflammation, 2015 Osteoporosis is one of the most common bone diseases, which is characterized by a systemic impairment of bone mass and fragility fractures. Age-related oxidative stress is highly associated with impaired osteoblastic dysfunctions and subsequent ...
Chong-xin Huang, Bo Lv, Yue Wang
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Protein phosphatase 2A anchoring disruptor gene therapy for familial dilated cardiomyopathy [PDF]
Molecular Therapy: Methods & Clinical DevelopmentFamilial dilated cardiomyopathy is a prevalent cause of heart failure that results from the mutation of genes encoding proteins of diverse function. Despite modern therapy, dilated cardiomyopathy typically has a poor outcome and is the leading cause of ...
Xueyi Li +4 more
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Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. [PDF]
, 2013 Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits.
Clarke, Steven G +3 more
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Protein phosphatase 2A - structure, function and role in neurodevelopmental disorders.
Journal of Cell Science, 2021 Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and schizophrenia, have high socioeconomic impact, yet poorly understood etiologies.
P. Sandal +4 more
semanticscholar +1 more source