Results 11 to 20 of about 573,078 (335)
Definitions, 2020 PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic ...
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Protein Phosphatase 2A Regulatory Protein [PDF]
Definitions, 2020 A subunit of protein phosphatase 2A that serves as a scaffold for the formation and localization of the holoenzyme complex and plays a role in the modulation of substrate specificity.
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Protein Phosphatase 2A Subunit Gene [PDF]
Definitions, 2020 T he Protein Phosphatase 2A Subunit Genes encodes 3 subunits (A, B, and C) of Protein Phosphatase 2A (PP2A) holoenzyme, a heterotrimeric serine/threonine phosphatase.
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Protein Phosphatase 2A Regulates Cardiac Na+ Channels [PDF]
Circulation Research, 2019 Rationale: Voltage-gated Na+ channel (INa) function is critical for normal cardiac excitability. However, the Na+ channel late component (INa,L) is directly associated with potentially fatal forms of congenital and acquired human arrhythmia. CaMKII (Ca2+/
Mona El Refaey +14 more
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FAM122A, a new endogenous inhibitor of protein phosphatase 2A
Oncotarget, 2016 The regulation of the ubiquitously expressed protein phosphatase 2A (PP2A) is essential for various cellular functions such as cell proliferation, transformation, and fate determination.
Li Fan +7 more
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Ceramide activates heterotrimeric protein phosphatase 2A.
Journal of Biological Chemistry, 1993 Ceramide activates a cytosolic protein phosphatase present in rat T9 glioma cells and rat brain. Ceramide-activated protein phosphatase (CAPP) was found to share several properties with protein phosphatase 2A (PP2A) leading to the hypothesis that ceramide may directly activate PP2A.
Rick T. DobrowskySS +3 more
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Bioengineered protein phosphatase 2A [PDF]
Bioengineered, 2013 Harmful algal blooms caused by phytoplankton can occur in all aquatic environments. Some of the algae present in these blooms are capable of producing extremely potent toxins. Due to climate change and eutrophication, harmful algal blooms are increasing on a global scale.
Juan A, Rubiolo +5 more
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Journal of Biological Chemistry, 2020 Protein phosphatase 2A (PP2A) critically regulates cell signaling and is a human tumor suppressor. PP2A complexes are modulated by proteins such as cancerous inhibitor of protein phosphatase 2A (CIP2A), protein phosphatase methylesterase 1 (PME-1), and ...
O. Kauko +19 more
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Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Frontiers in Cellular Neuroscience, 2022 Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform ...
Keunjung Heo +11 more
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PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
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