ASPPs multimerize protein phosphatase 1. [PDF]
PLoS GeneticsProtein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown.
Derek T Wei +7 more
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Protein Phosphatase-1 Regulates Expression of Neuregulin-1 [PDF]
Biology, 2016 Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova +7 more
doaj +3 more sources
Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein–protein interaction [PDF]
Nature Communications, 2023 Protein phosphatase 1 (PP1) is regulated by intrinsically disordered proteins like inhibitor-3, I3. The authors show that I3 does not inhibit PP1 by forming a rigid complex but instead by binding dynamically with its active site metals, showing how ...
Gautam Srivastava +4 more
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Protein phosphatase 1 regulates core PCP signaling. [PDF]
EMBO Rep, 2023 AbstractPCP signaling polarizes epithelial cells within the plane of an epithelium. Core PCP signaling components adopt asymmetric subcellular localizations within cells to both polarize and coordinate polarity between cells. Achieving subcellular asymmetry requires additional effectors, including some mediating post-translational modifications of core
Song S +13 more
europepmc +6 more sources
Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. [PDF]
PLoS ONE, 2012 Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. We previously identified PFN1 as a huntingtin aggregation inhibitor, and others have implicated it as a ...
Jieya Shao, Marc I Diamond
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Mapping the Protein Phosphatase 1 Interactome in Human Cytomegalovirus Infection [PDF]
VirusesProtein phosphorylation is a crucial regulatory mechanism in cellular homeostasis. The human cytomegalovirus (HCMV) incorporates protein phosphatase 1 (PP1) into its tegument, yet the biological relevance and mechanisms of this incorporation remain ...
Stefan Weinberger +4 more
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PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis [PDF]
Biomolecules, 2023 Raf-1, a multifunctional kinase, regulates various cellular processes, including cell proliferation, apoptosis, and migration, by phosphorylating MAPK/ERK kinase and interacting with specific kinases.
Jason A. Kirkbride +7 more
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Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription [PDF]
Retrovirology, 2005 Background HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA.
Brady John +4 more
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Protein Phosphatase 1 Regulatory Subunit 3: A Prognostic Biomarker in Stomach Adenocarcinoma [PDF]
International Journal of General Medicine, 2022 Ya-Zhen Zhu,1 Xi-Wen Liao,2 Wu Yin,1 Hai-Ming Wei1 1Department of Pathology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People’s Republic of China; 2Department of Hepatobiliary Surgery, The First Affiliated Hospital of ...
Zhu YZ, Liao XW, Yin W, Wei HM
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PPP1R2 stimulates protein phosphatase-1 through stabilisation of dynamic subunit interactions [PDF]
Nature CommunicationsProtein Ser/Thr phosphatase PP1 is always associated with one or two regulatory subunits or RIPPOs. One of the earliest evolved RIPPOs is PPP1R2, also known as Inhibitor-2.
Sarah Lemaire +11 more
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