Results 71 to 80 of about 446,560 (302)

Structural basis of protein phosphatase 2A stable latency [PDF]

Nature Communications, 2013
The catalytic subunit of protein phosphatase 2A (PP2Ac) is stabilized in a latent form by α4, a regulatory protein essential for cell survival and biogenesis of all PP2A complexes. Here we report the structure of α4 bound to the N-terminal fragment of PP2Ac.
Jiang, Li, Stanevich, Vitali, Satyshur, Kenneth A, Kong, Mei, Watkins, Guy R., Wadzinski, Brian E., Sengupta, Rituparna, Xing, Yongna   +7 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

Protein phosphatases 1, 2A, and 2C are protein histidine phosphatases.

Journal of Biological Chemistry, 1993
Eukaryotic cellular proteins contain phosphohistidine. To search for protein histidine phosphatases, protein histidine kinase from Saccharomyces cerevisiae was used to phosphorylate histone H4 on histidine at position 75 in the H4 amino acid sequence. Incubation of the phosphorylated histone H4 with either protein phosphatase 1, 2A, or 2C resulted in ...
Kim, Y., Huang, J., Cohen, P., Matthews, H. R.   +3 more
openaire   +2 more sources

Protein phosphatase 2A: a target for anticancer therapy [PDF]

The Lancet Oncology, 2013
Protein phosphatase 2A (PP2A), one of the main serine-threonine phosphatases in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven intracellular signalling pathways. Unrestrained activation of oncogenic kinases together with inhibition of tumour suppressors is often required for development of cancer.
Danilo, Perrotti, Paolo, Neviani
openaire   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein

Frontiers in Aging Neuroscience, 2018
The pathology of Parkinson’s disease (PD) is characterized by intracellular neurofibrillary tangles of phosphorylated α-synuclein (α-syn). Protein phosphatase 2A (PP2A) is responsible for α-syn dephosphorylation. Previous work has demonstrated that α-syn
Hao Tian, Yongquan Lu, Jia Liu, Weijin Liu, Lingling Lu, Chunli Duan, Ge Gao, Hui Yang   +7 more
doaj   +1 more source

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

Nature Communications, 2023
Tumour suppressors are inhibited in cancers and their reactivation could provide novel therapy opportunities. Here, the authors study the structural mechanism by which human tumour suppressor Protein Phosphatase 2A is inhibited in breast cancer cells by ...
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck   +21 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Inhibition of protein phosphatase-1 and -2A by ellagitannins: structure-inhibitory potency relationships and influences on cellular systems

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Several ellagitannins inhibited the activity of protein phosphatase-1 (PP1) and -2 A (PP2A) catalytic subunits (PP1c and PP2Ac) with preferential suppression of PP1c over PP2Ac.
Zoltán Kónya, Bálint Bécsi, Andrea Kiss, Dániel Horváth, Mária Raics, Katalin E. Kövér, Beáta Lontay, Ferenc Erdődi   +7 more
doaj   +1 more source