Results 271 to 280 of about 750,523 (310)

Zinc finger DHHC-type palmitoyltransferase 13-mediated S-palmitoylation of GNA13 from Sertoli cell-derived extracellular vesicles inhibits autophagy in spermatogonial stem cells. [PDF]

Cell Commun Signal
Cao H, Gao H, Li Y, Li L, Liu S, Jin T, Wang Y, Gong Y, Yuan S, Dong W.   +9 more
europepmc   +1 more source

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

Advanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni, Jian Tan, Julen Reyes, Alistair M Senior, Caitlin Andrews, Jemma Taitz, Camille Potier‐Villette, Claire Wishart, Alanna Spiteri, Laura Piccio, Nicholas Jonathan Cole King, Romain Barrès, David Raubenheimer, Stephen James Simpson, Ralph Nanan, Laurence Macia   +15 more
wiley   +1 more source

PTMD 2.0: an updated database of disease-associated post-translational modifications. [PDF]

Nucleic Acids Res
Huang X, Feng Z, Liu D, Gou Y, Chen M, Tang D, Han C, Peng J, Peng D, Xue Y.   +9 more
europepmc   +1 more source

Delivery of Human iPSC‐Derived RPE Cells in Healthy Minipig Retina Results in Interaction Between Photoreceptors and Transplanted Cells

Advanced Science, EarlyView.
Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová, Francisco Javier Rodriguez‐Jimenez, Annika Konrad, Yaroslav Nemesh, Muhammed Arshad Thottappali, Ana Artero‐Castro, Ruslan Nyshchuk, Anastasiia Kolesnikova, Brigitte Müller, Hana Studenovska, Jana Juhasova, Stefan Juhas, Ivona Valekova, Dunja Lukovic, Claudia Aleman, Taras Ardan, Saskia Drutovič, Jan Motlik, Zdenka Ellederova, Zbinek Straňák, Miroslav Veith, Lyubomyr Lytvynchuk, Ruchi Sharma, Kapil Bharti, Goran Petrovski, Pavla Jendelova, Knut Stieger, Slaven Erceg   +27 more
wiley   +1 more source

Role of human herpesvirus homologs of infected cell protein 27 (ICP27) in the biogenesis, processing, and maturation of mRNAs. [PDF]

mBio
Soto-Machuca AA, Ortiz GE, Carbone-Schellman J, Pastén-Ferrada IA, Retamal-Díaz A, Kalergis AM, González PA.   +6 more
europepmc   +1 more source

A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery

Advanced Science, EarlyView.
Knowledge‐Guided Drug Relational Predictor (KGDRP), a graph representation learning approach, effectively integrates multiple omics data, including biological network data, gene expression data, and sequence data that incorporates chemical molecular structures.
Qing Ye, Yundian Zeng, Linlong Jiang, Yu Kang, Peichen Pan, Jiming Chen, Yafeng Deng, Haitao Zhao, Shibo He, Tingjun Hou, Chang‐Yu Hsieh   +10 more
wiley   +1 more source

Impact of a Heterozygous C1R^R301P/WT Mutation on Collagen Metabolism and Inflammatory Response in Human Gingival Fibroblasts. [PDF]

Cells
Qu C, Koskinen Holm C.
europepmc   +1 more source

ROS‐Activated Nanohydrogel Scaffolds with Multi‐Factors Controlled Release for Targeted Dual‐Lineage Repair of Osteochondral Defects

Advanced Science, EarlyView.
ROS‐activated nanohydrogels composite bilayer scaffolds are rationally designed for targted dual‐lineage repair of osteochondral defects. The as‐prepared nanohydrogel scaffolds provided 3D culture and induced dual‐lineage differentiation of BMSCs in vitro, efficiently inhibited early‐stage inflammation by rapidly releasing DS and improved cartilage and
Xiuhui Wang, Shunli Wu, Ruiyang Li, Huijian Yang, Yue Sun, Zijie Cao, Xiao Chen, Yan Hu, Hao Zhang, Zhen Geng, Long Bai, Zhongmin Shi, Ke Xu, Hongbo Tan, Jiacan Su   +14 more
wiley   +1 more source

Bio-nanopore technology for biomolecules detection. [PDF]

Adv Biotechnol (Singap)
Li P, Liang D, Yang E, Zeb M, Huang H, Sun H, Zhang W, Peng C, Zhao Y, Ma W.   +9 more
europepmc   +1 more source