Results 11 to 20 of about 2,150,536 (302)
Modulating protein quality control
eLife, 2016 Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
Lars Plate +3 more
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Protein quality control of cell stemness [PDF]
Cell Regeneration, 2020 Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis.
Pengze Yan +4 more
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Protein Quality Control in the Nucleus [PDF]
Biomolecules, 2014 In their natural environment, cells are regularly exposed to various stress conditions that may lead to protein misfolding, but also in the absence of stress, misfolded proteins occur as the result of mutations or failures during protein synthesis. Since
Sofie V. Nielsen +3 more
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Mitochondrial Protein Quality Control Mechanisms [PDF]
Genes, 2020 Mitochondria serve as a hub for many cellular processes, including bioenergetics, metabolism, cellular signaling, redox balance, calcium homeostasis, and cell death. The mitochondrial proteome includes over a thousand proteins, encoded by both the mitochondrial and nuclear genomes.
Pooja Jadiya, Dhanendra Tomar
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Ribosome-associated protein quality control [PDF]
Nature Structural & Molecular Biology, 2016 Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA, insufficient availability of charged tRNAs and genetic errors. All organisms have evolved mechanisms to recognize stalled ribosomes and initiate pathways for recycling, quality control and stress signaling. Here we review the discovery and molecular dissection of the
Onn, Brandman, Ramanujan S, Hegde
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Quality Control of Orphaned Proteins [PDF]
Molecular Cell, 2018 The billions of proteins inside a eukaryotic cell are organized among dozens of sub-cellular compartments, within which they are further organized into protein complexes. The maintenance of both levels of organization is crucial for normal cellular function. Newly made proteins that fail to be segregated to the correct compartment or assembled into the
Szymon, Juszkiewicz, Ramanujan S, Hegde
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N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth
Redox Biology, 2022 Despite the evidences of elevated expression of Mer tyrosine kinase (MerTK) in multiple human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular carcinoma (HCC) remains undefined. We explored the functional effects of MerTK and
Yongzhang Liu +13 more
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Cell & Bioscience, 2022 Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN.
Thomas Fischer +16 more
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Molecular Oncology, 2022 Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia +14 more
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Charactering the spoilage mechanism of “three sticks” of Jinhua ham
Food Science and Human Wellness, 2022 To investigate the spoilage characteristics of Jinhua ham, sensory scores, volatile compounds, biogenic amine, physicochemical parameters and microbial counts were evaluated between normal and spoiled hams.
Changyu Zhou +6 more
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