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Protein quality control at the mitochondrion
Essays in Biochemistry, 2016Mitochondria are essential constituents of a eukaryotic cell by supplying ATP and contributing to many mayor metabolic processes. As endosymbiotic organelles, they represent a cellular subcompartment exhibiting many autonomous functions, most importantly containing a complete endogenous machinery responsible for protein expression, folding and ...
Wolfgang, Voos +3 more
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Protein Quality Control in the Bacterial Periplasm
Annual Review of Microbiology, 2011Protein quality control involves sensing and treatment of defective or incomplete protein structures. Misfolded or mislocalized proteins trigger dedicated signal transduction cascades that upregulate the production of protein quality-control factors. Corresponding proteases and chaperones either degrade or repair damaged proteins, thereby reducing the
Merdanovic, Melisa +4 more
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Protein Quality Control in Cardiomyocytes
2012Protein quality control (PQC) plays an indispensable role in maintaining protein homeostasis in cardiomyocytes. PQC is a fundamental cellular process, whose role it is to sense and repair misfolded/unfolded proteins and, if the repair fails, degrade the terminally misfolded polypeptides through an intricate collaboration between molecular chaperones ...
Xuejun Wang, Cam Patterson
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Quality control: ER-associated degradation: protein quality control and beyond.
The Journal of cell biology, 2014Even with the assistance of many cellular factors, a significant fraction of newly synthesized proteins ends up misfolded. Cells evolved protein quality control systems to ensure that these potentially toxic species are detected and eliminated. The best characterized of these pathways, the ER-associated protein degradation (ERAD), monitors the folding ...
Annamaria, Ruggiano +2 more
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Quality control of the mitochondrial proteome
Nature Reviews Molecular Cell Biology, 2020Johannes M Herrmann, Thomas Becker
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Mechanisms of substrate processing during ER-associated protein degradation
Nature Reviews Molecular Cell Biology, 2023Thomas Sommer
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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Nature Reviews Molecular Cell Biology, 2021Simon Alberti, Anthony A Hyman
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Quality control of protein drugs.
Arzneimittel-Forschung, 1988Testing of protein drugs must include assays for purity, identity, safety, and potency. The structure of the final product as well as potential impurities are strongly influenced by the type of producing organism (bacteria, yeast, mammalian or insect cells).
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Time to add screening for financial hardship as a quality measure?
Ca-A Cancer Journal for Clinicians, 2021Cathy J Bradley +2 more
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Glycosylation-directed quality control of protein folding
Nature Reviews Molecular Cell Biology, 2015Davis T W Ng
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