Results 271 to 280 of about 19,078,260 (300)
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Import and quality control of peroxisomal proteins
Journal of Cell Science, 2023ABSTRACT Peroxisomes are involved in a multitude of metabolic and catabolic pathways, as well as the innate immune system. Their dysfunction is linked to severe peroxisome-specific diseases, as well as cancer and neurodegenerative diseases.
Markus Rudowitz, Ralf Erdmann
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Protein Quality Control in the Bacterial Periplasm
Annual Review of Microbiology, 2011Protein quality control involves sensing and treatment of defective or incomplete protein structures. Misfolded or mislocalized proteins trigger dedicated signal transduction cascades that upregulate the production of protein quality-control factors. Corresponding proteases and chaperones either degrade or repair damaged proteins, thereby reducing the
Merdanovic, Melisa +4 more
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Protein Quality Control in Mitochondria
Journal of Biochemistry, 2009Mitochondria are crucial for both life and death of eukaryotic cells. Compromised mitochondrial integrity has severe cellular consequences and is linked to senescence and neurodegenerative disorders in humans. To maintain the functionality of proteins in mitochondria, quality-control mechanisms including signal transduction pathways counteracting ...
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Quality Control: Proteins and Organelles
Biochemistry (Moscow), 2002This review summarizes materials on the mechanisms of intracellular degradation of proteins whose topogenesis is disturbed at one stage or another. Chaperone and proteolytic systems involved in this process in the endoplasmic reticulum, mitochondria, and chloroplasts of eucaryotic cells as well as those in distinct subcellular compartments of ...
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Nucleolus: A Protein Quality Control Compartment
Trends in Biochemical Sciences, 2019Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat-shock protein (Hsp)70-dependent manner.
Rekulapally, Pavani, Suresh, S N
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Protein quality control at the endoplasmic reticulum
Essays in Biochemistry, 2016The ER (endoplasmic reticulum) is the protein folding ‘factory’ of the secretory pathway. Virtually all proteins destined for the plasma membrane, the extracellular space or other secretory compartments undergo folding and maturation within the ER. The ER hosts a unique PQC (protein quality control) system that allows specialized modifications such as ...
McCaffrey, Kathleen, Braakman, Ineke
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Coping with Protein Quality Control Failure
Annual Review of Cell and Developmental Biology, 2017Cells and organisms have evolved numerous mechanisms to cope with and to adapt to unexpected challenges and harsh conditions. Proteins are essential to perform the vast majority of cellular and organismal functions. To maintain a healthy proteome, cells rely on a network of factors and pathways collectively known as protein quality control (PQC ...
Esther, Pilla +2 more
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New developments for protein quality control
Science, 2017A unique enzyme promotes degradation of misfolded proteins and differentiation of red blood ...
Randolph Y, Hampton +1 more
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Protein Quality Control in Neurodegenerative Disease
2012The accumulation of misfolded proteins is a common feature of many neurodegenerative diseases. These observations suggest a potential link between these disorders and protein quality control, a collection of cellular pathways that sense damage to proteins and facilitate their turnover. Consistent with this idea, activation of quality control components,
Jason E, Gestwicki, Dan, Garza
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Prion proteins meet protein quality control
Trends in Cell Biology, 2003Recent work on transmissible spongiform encephalopathies (TSEs) suggests a role for protein quality-control mechanisms in both prion protein aggregation and pathogenesis. Cytosolic accumulation of prion protein seems to be neurotoxic and might occur when proteasome function is compromised and quality control is overwhelmed. These findings are discussed
Derek E, Dimcheff +2 more
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