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Quality Control: Proteins and Organelles
Biochemistry (Moscow), 2002This review summarizes materials on the mechanisms of intracellular degradation of proteins whose topogenesis is disturbed at one stage or another. Chaperone and proteolytic systems involved in this process in the endoplasmic reticulum, mitochondria, and chloroplasts of eucaryotic cells as well as those in distinct subcellular compartments of ...
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Protein Quality Control Degradation in the Nucleus
Annual Review of Biochemistry, 2018Nuclear proteins participate in diverse cellular processes, many of which are essential for cell survival and viability. To maintain optimal nuclear physiology, the cell employs the ubiquitin-proteasome system to eliminate damaged and misfolded proteins in the nucleus that could otherwise harm the cell.
Charisma, Enam +3 more
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Protein Quality Control in Neurodegenerative Disease
2012The accumulation of misfolded proteins is a common feature of many neurodegenerative diseases. These observations suggest a potential link between these disorders and protein quality control, a collection of cellular pathways that sense damage to proteins and facilitate their turnover. Consistent with this idea, activation of quality control components,
Jason E, Gestwicki, Dan, Garza
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Coping with Protein Quality Control Failure
Annual Review of Cell and Developmental Biology, 2017Cells and organisms have evolved numerous mechanisms to cope with and to adapt to unexpected challenges and harsh conditions. Proteins are essential to perform the vast majority of cellular and organismal functions. To maintain a healthy proteome, cells rely on a network of factors and pathways collectively known as protein quality control (PQC ...
Esther, Pilla +2 more
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New developments for protein quality control
Science, 2017A unique enzyme promotes degradation of misfolded proteins and differentiation of red blood ...
Randolph Y, Hampton +1 more
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Protein quality control at the endoplasmic reticulum
Essays in Biochemistry, 2016The ER (endoplasmic reticulum) is the protein folding ‘factory’ of the secretory pathway. Virtually all proteins destined for the plasma membrane, the extracellular space or other secretory compartments undergo folding and maturation within the ER. The ER hosts a unique PQC (protein quality control) system that allows specialized modifications such as ...
McCaffrey, Kathleen, Braakman, Ineke
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Prion proteins meet protein quality control
Trends in Cell Biology, 2003Recent work on transmissible spongiform encephalopathies (TSEs) suggests a role for protein quality-control mechanisms in both prion protein aggregation and pathogenesis. Cytosolic accumulation of prion protein seems to be neurotoxic and might occur when proteasome function is compromised and quality control is overwhelmed. These findings are discussed
Derek E, Dimcheff +2 more
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Protein Quality Control in Plant Organelles: Current Progress and Future Perspectives
Molecular Plant, 2021Jin-Yu Li +2 more
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Protein Quality in Perspective: A Review of Protein Quality Metrics and Their Applications
Nutrients, 2022Shiksha Adhikari +2 more
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Microalgae as Sources of High-Quality Protein for Human Food and Protein Supplements
Foods, 2021Yanwen Wang +2 more
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