Results 31 to 40 of about 2,150,536 (302)
SGTA regulates the cytosolic quality control of hydrophobic substrates [PDF]
, 2014 Hydrophobic amino acids are normally shielded from the cytosol and their exposure is often used as an indicator of protein misfolding to enable the chaperone-mediated recognition and quality control of aberrant polypeptides.
High, Stephen +3 more
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Quality control of protein complex composition
Molecular Cell, 2022 Eukaryotic cells possess hundreds of protein complexes that contain multiple subunits and must be formed at the correct time and place during development. Despite specific assembly pathways, cells frequently encounter complexes with missing or aberrant subunits that can disrupt important signaling events.
Chris Padovani +2 more
openaire +2 more sources
Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]
, 2019 Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D. +3 more
core +1 more source
The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]
, 2018 PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core +2 more sources
Quality control in protein synthesis [PDF]
Biochimie, 2015 Editorial: In all living cells, protein synthesis (also named translation) is a complex and dynamic process mediated by the ribosome. It allows for an accurate correspondence between the genetic information and newly synthesized proteins. While the basics of translation have been known for several decades, the details of how ribosomes perform their ...
openaire +3 more sources
Quality control of overexpressed membrane proteins [PDF]
Proceedings of the National Academy of Sciences, 2008 Overexpression of membrane proteins in Escherichia coli frequently leads to the formation of aggregates or inclusion bodies, which is undesirable for most studies. Ideally, one would like to optimize the expression conditions by monitoring simultaneously and rapidly both the amounts of ...
Geertsma, Eric R. +3 more
openaire +3 more sources
Ubiquitin receptors and protein quality control [PDF]
Journal of Molecular and Cellular Cardiology, 2013 Protein quality control (PQC) is essential to intracellular proteostasis and is carried out by sophisticated collaboration between molecular chaperones and targeted protein degradation. The latter is performed by proteasome-mediated degradation, chaperone-mediated autophagy (CMA), and selective macroautophagy, and collectively serves as the final line ...
Xuejun, Wang, Erin J M, Terpstra
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Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]
, 2012 Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Aksam +58 more
core +4 more sources
Protein Quality Control at the Mitochondrial Surface
Frontiers in Cell and Developmental Biology, 2021 Mitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of ...
Fabian den Brave +2 more
doaj +1 more source
The protein quality control and neurodegeneration
Folia Pharmacologica Japonica, 2003 There are growing lines of evidence addressing a potential link between failure of protein quality control and neurodegeneration. Hence, it is important to know the quality control mechanism of the cell for understanding the molecular basis underlying neurodegenerative diseases.
Keiji, Tanaka, Shigeo, Murata
openaire +3 more sources