Results 41 to 50 of about 2,150,536 (302)

Protein quality control meets transcriptome remodeling under stress

Cell Stress, 2017
To tolerate and recover from genotoxic stress cells must coordinate a range of stress response activities including cell cycle arrest, DNA repair, and remodeling of the transcriptome and proteome.
Veena Mathew, Peter C. Stirling
doaj   +1 more source

Methionine Redox Homeostasis in Protein Quality Control

Frontiers in Molecular Biosciences, 2021
Bacteria live in different environments and are subject to a wide variety of fluctuating conditions. During evolution, they acquired sophisticated systems dedicated to maintaining protein structure and function, especially during oxidative stress.
Laurent Aussel, Benjamin Ezraty
doaj   +1 more source

Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses [PDF]

, 2016
ACKNOWLEDGMENTS We thank Dennis Winge (University of Utah) and the members of the Khalimonchuk laboratory for critical comments. We also thank Christoph Schuller (University of Natural Resources, Austria) and Paul Herman (Ohio State University) for ...
Barrientos, Antoni, Bohovych, Iryna, Brown, Alistair J.P., Christianson, Sara, Fangman, Teresa, Kastora, Stavroula, Khalimonchuk, Oleh, Kim, Heejeong, Lee, Jaekwon, Topil, Danelle, Zhou, You J.   +10 more
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Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq. [PDF]

, 2019
One of the primary aims of the Functional Annotation of ANimal Genomes (FAANG) initiative is to characterize tissue-specific regulation within animal genomes.
Bellone, Rebecca R, Creppe, Catherine, Finno, Carrie J, Hales, Erin N, Kalbfleisch, TS, Kern, Colin, Kingsley, NB, MacLeod, James N, Petersen, Jessica L, Zhou, Huaijun   +9 more
core   +2 more sources

Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]

, 2020
To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju, Duan, Yaoyun, Fan, Feifei, Fang, Xi, Huang, Lei, Jia, Nan, Li, Yali, Liu, Jie, Ouyang, Kunfu, Tang, Huayuan, Trexler, Christa, Wang, Gang, Wang, Hong, Yang, Feili   +13 more
core  

ValiDichro: a website for validating and quality control of protein circular dichroism spectra [PDF]

, 2013
Circular dichroism (CD) spectroscopy is widely used in structural biology as a technique for examining the structure, folding and conformational changes of proteins. A new server, ValiDichro, has been developed for checking the quality and validity of CD
Abdul-Gader, B. A. Wallace, Benjamin Woollett, Berman, Davis, Dutta, Europe, Council of, Greenfield, Guideline Q6B, Hekkelman, Hooft, Jones, Kelly, Lancashire, Laskowski, Lee Whitmore, Lees, Lees, Miles, Miles, Miles, Nordén, Patwardhan, Ravi, Robert W. Janes, Savitzky, Wallace, Wallace, Westbrook, Whitmore, Whitmore, Whitmore, Woollett   +32 more
core   +1 more source

Quality control of integral membrane proteins

Trends in Biochemical Sciences, 2004
Integral membrane proteins (IMPs) are essential components of the plasma and organellar membranes of the eukaryotic cell. Non-native IMPs, which can arise as a result of mutations, errors during biosynthesis or cellular stress, can disrupt these membranes and potentially lead to cell death.
Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32610, USA ( host institution ), Krebs, Mark P. ( author ), Noorwez, Syed M. ( author ), Malhotra, Ritu ( author ), Kaushal, Shalesh ( author )   +4 more
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Cellular Strategies of Protein Quality Control [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Eukaryotic cells must contend with a continuous stream of misfolded proteins that compromise the cellular protein homeostasis balance and jeopardize cell viability. An elaborate network of molecular chaperones and protein degradation factors continually monitor and maintain the integrity of the proteome. Cellular protein quality control relies on three
Bryan, Chen, Marco, Retzlaff, Thomas, Roos, Judith, Frydman   +3 more
openaire   +2 more sources

Ocins for Food Safety

Frontiers in Microbiology, 2019
The food industry produces highly perishable products. Food spoilage represents a severe problem for food manufacturers. Therefore, it is important to identify effective preservation solutions to prevent food spoilage.
Shilja Choyam, Shilja Choyam, Alok Kumar Srivastava, Jae-Ho Shin, Rajagopal Kammara, Rajagopal Kammara   +5 more
doaj   +1 more source

Differential Scales of Protein Quality Control [PDF]

Cell, 2014
Proteins are notorious for their unpleasant behavior-continually at risk of misfolding, collecting damage, aggregating, and causing toxicity and disease. To counter these challenges, cells have evolved elaborate chaperone and quality control networks that can resolve damage at the level of the protein, organelle, cell, or tissue. On the smallest scale,
Wolff, Suzanne, Weissman, Jonathan S., Dillin, Andrew   +2 more
openaire   +2 more sources