Results 51 to 60 of about 2,150,536 (302)

Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

eLife, 2020
The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Lan Wang, Alexander Myasnikov, Xingjie Pan, Peter Walter   +3 more
doaj   +1 more source

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]

, 2014
The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R, Daniel East, Decaudin D, Garnier M, Gatliff J, Hirsch JD, James Crosby, Jemma Gatliff, Krueger KE, Li H, Michelangelo Campanella, Miettinen H, Okatsu K, Ozawa K, Papadopoulos V, Peter Parker, Robert Harvey, Rosella Abeti, Seneviratne MS, Sileikyte J, Snyder SH, Tamse CT, William Craigen   +22 more
core   +3 more sources

Molecular Chaperones in Protein Quality Control

BMB Reports, 2005
Proteins must fold into their correct three-dimensional conformation in order to attain their biological function. Conversely, protein aggregation and misfolding are primary contributors to many devastating human diseases, such as prion-mediated infections, Alzheimer's disease, type II diabetes and cystic fibrosis.
Sukyeong, Lee, Francis T F, Tsai
openaire   +3 more sources

Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions

Cells
As ovarian cancer progresses, increased glucose use causes a glucose shortage in the tumor microenvironment. Therefore, it is crucial to find drugs that can effectively kill cancer cells in this energy stress setting.
Yulun Wu, Ziying Zhang, Minhui Ren, Yao Chen, Jingying Zhang, Jiarui Li, Feng Gao, Yongli Bao, Yanxin Huang, Xiaoguang Yang, Zhenbo Song   +10 more
doaj   +1 more source

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

Journal of Advanced Research
Introduction: Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear.
Yulun Wu, Chaoran Jia, Wei Liu, Wei Zhan, Yao Chen, Junlin Lu, Yongli Bao, Shuyue Wang, Chunlei Yu, Lihua Zheng, Luguo Sun, Zhenbo Song   +11 more
doaj   +1 more source

Quality control by a mobile molecular workshop: quality versus quantity

, 2010
Ribosome is a molecular machine that moves on a mRNA track while, simultaneously, polymerizing a protein using the mRNA also as the corresponding template.
Chowdhury, Debashish, Sharma, Ajeet K.
core   +1 more source

Experimental data from flesh quality assessment and shelf life monitoring of high pressure processed European sea bass (Dicentrarchus labrax) fillets [PDF]

, 2019
Fresh fish are highly perishable food products and their short shelf-life limits their commercial exploitation and leads to waste, which has a negative impact on aquaculture sustainability.
Aken, Anjo, Codoñer, Collins, Deutsch, Fu, Gillet, Hulsen, Klindworth, Laemmli, Lambert, Pazos, Perez-Riverol, Placzek, Santa, Sigurgisladottir, The UniProt Consortium, Tine, Toju, Tsironi   +19 more
core   +1 more source

Mitochondrial protein synthesis quality control

Human Molecular Genetics
Abstract Human mitochondrial DNA is one of the most simplified cellular genomes and facilitates compartmentalized gene expression. Within the organelle, there is no physical barrier to separate transcription and translation, nor is there evidence that quality control surveillance pathways are active to prevent translation on faulty mRNA ...
Lidiia Koludarova, Brendan J Battersby
openaire   +3 more sources

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. [PDF]

PLoS Genetics, 2014
Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels. However, how the cell integrates RNA-processing programs with post-translational protein quality control systems is unknown ...
Tao Zhang, Gerard Baldie, Goran Periz, Jiou Wang   +3 more
doaj   +1 more source