Results 81 to 90 of about 2,150,536 (302)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Antioxidant and antihypertensive activities of rice bran peptides [PDF]

, 2011
Protein isolates and peptide fractions from food sources (cereal grains), have been shown to exert bioactive properties including antiobesity, anticancer, antiangiogenic, etc.
Hettiarachchy, Navam S., Hull, Janika, Kannan, Arvind   +2 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Endoplasmic Reticulum-Mediated Protein Quality Control in Arabidopsis

Frontiers in Plant Science, 2014
A correct three-dimensional structure is crucial for the physiological functions of a protein, yet the folding of proteins to acquire native conformation is a fundamentally error-prone process.
Jianming eLi, Yidan eLiu
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development

mBio, 2020
Chlamydia trachomatis is an obligate intracellular bacterium that undergoes a complex developmental cycle in which the bacterium differentiates between two functionally and morphologically distinct forms, the elementary body (EB) and reticulate body (RB),
Nicholas A. Wood, Amanda M. Blocker, Mohamed A. Seleem, Martin Conda-Sheridan, Derek J. Fisher, Scot P. Ouellette   +5 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. [PDF]

, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Chetlapalli, Keerthana, Goodman, Jay S, Jorgens, Danielle M, King, Grant A, McDonald, Kent L, Schick, Jennifer G, Ünal, Elçin   +6 more
core   +1 more source

Ubiquitin and Parkinson's disease through the looking glass of Genetics [PDF]

, 2017
Biochemical alterations found in the brains of Parkinson's disease (PD) patients indicate that cellular stress is a major driver of dopaminergic neuronal loss.
Abdul Rehman, Alexopoulou, Bedford, Berndsen, Bousquet-Dubouch, Brahmachari, Burchell, Caulfield, Chan, Chang, Chaugule, Chaugule, Chen, Chen, Chen, Chung, Ciehanover, Conedera, Dawson, Di Fonzo, Duda, Fabre, Fauvet, Fiesel, Geisler, Gitler, Goedert, Goldstein, Gündüz, Helen Walden, Heo, Hernandez, Hershko, Hertz, Hjerpe, Hristova, Hsu, Kane, Kang, Kazlauskaite, Kazlauskaite, Kazlauskaite, Kazlauskaite, Kelsall, Kirk, Kitada, Ko, Komander, Kondapalli, Kordower, Koyano, Kuiken, Kumar, Lai, Laman, Lazarou, Lazarou, Lee, Leutenegger, Liani, Lohmann, Lowe, Lydeard, Matheoud, Matsuda, McLelland, McNaught, McNaught, McWilliams, Meziane, Miratul M.K. Muqit, Mulherkar, Na, Narendra, Narendra, Nelson, Nelson, Nguyen, Norris, Nuytemans, Ordureau, Ordureau, Ordureau, Paisan-Ruiz, Pao, Pickrell, Puschmann, Rahighi, Randle, Randle, Riley, Samaranch, Samuel, Sarraf, Sauve, Shimura, Shojaee, Smit, Song, Spratt, Spratt, Steele, Stephenson, Stieglitz, Sugiura, Sun, Takanashi, Teixeira, Tetzlaff, Tofaris, Trempe, Trujillo, Tsou, Vaibhava, Valente, Vingill, Vives-Bauza, Wai, Walden, Wauer, Wauer, Wauer, Wenzel, Yalcin-Cakmakli, Yamano, Ye, Yerbury, Zaiss, Zaiss, Zhang, Zhao, Zimmerman   +131 more
core   +5 more sources

Quality Control and Protein Microarrays [PDF]

Clinical Chemistry, 2009
The scale of testing required in clinical analysis has of necessity driven analytical methods to a variety of multiplexed formats. A single assay in a test tube has evolved to automated multiple testing in cuvettes in multicuvette carousels, or wells of a microplate with up to 9600 wells (1).
Stephen R Master, Larry J Kricka
openaire   +1 more source