Results 31 to 40 of about 31,021 (196)

Detection of Heterogeneous Protein S-Acylation in Cells [PDF]

, 2019
The use of synthetically synthesized azide and alkyne fatty acid analogs coupled with bioorthogonal Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction-based detection methods to study protein S-acylation reactions has replaced the traditional method of using in vivo metabolic radiolabeling with tritiated palmitic acid and has greatly ...
Greaves, Jennifer, Tomkinson, Nicholas C. O.   +1 more
openaire   +4 more sources

Development of an Acrylamide-Based Inhibitor of Protein S-Acylation [PDF]

, 2021
Protein S-acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, the installation of the lipid onto target proteins is catalyzed by a family of 23 Asp-His-His-Cys domain-containing protein acyltransferases (DHHC-PATs).
Saara-Anne Azizi, Tong Lan, Clémence Delalande, Rahul Kathayat, Bryan Dickinson   +4 more
openaire   +1 more source

Therapeutic targeting of protein S-acylation for the treatment of disease [PDF]

Biochemical Society Transactions, 2019
The post-translational modification protein S-acylation (commonly known as palmitoylation) plays a critical role in regulating a wide range of biological processes including cell growth, cardiac contractility, synaptic plasticity, endocytosis, vesicle trafficking, membrane transport and biased-receptor signalling.
Niall J. Fraser, Jacqueline Howie, Krzysztof J. Wypijewski, William Fuller   +3 more
openaire   +3 more sources

Dynamic Characterization of Protein and Posttranslational Modification Levels in Mycobacterial Cholesterol Catabolism

mSystems, 2020
Cholesterol of the host macrophage membrane is vital for mycobacterial infection, replication, and persistence. During chronic infection within host lung tissues, cholesterol facilitates the phagocytosis of mycobacteria into macrophages.
Jun-Yu Xu, Lei Zhao, Ying Xu, Bolin Li, Linhui Zhai, Minjia Tan, Bang-Ce Ye   +6 more
doaj   +3 more sources

Assaying protein palmitoylation in plants

Plant Methods, 2008
Background Protein S-acylation (also known as palmitoylation) is the reversible post-translational addition of acyl lipids to cysteine residues in proteins through a thioester bond. It allows strong association with membranes.
Taylor Laura, Hemsley Piers A, Grierson Claire S   +2 more
doaj   +1 more source

Protein S-acylation: Pathological mechanisms and novel therapeutic targets for diabetic complications. [PDF]

Chin Herb Med
Diabetes involves multi-organ complications that seriously threaten human life and health, and has become a major public health problem of global concern. Unfortunately, clinical management strategies for diabetic complications are still in their "infancy", restricted by a limited understanding of their complex pathological mechanism.
Liu R, Xu N, Song X, Li Y, Bu J, Su R, Guo H, Jiang C, Zhuang P, Zhang Y, Yin Q.   +10 more
europepmc   +3 more sources

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1. [PDF]

PLoS ONE, 2016
Expansion of the polyglutamine (polyQ) tract in the huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited movement disorder linked to neurodegeneration in the striatum and cortex.
Chun-Lun Ni, Divya Seth, Fabio Vasconcelos Fonseca, Liwen Wang, Tsan Sam Xiao, Phillip Gruber, Man-Sun Sy, Jonathan S Stamler, Alan M Tartakoff   +8 more
doaj   +1 more source

A novel yeast-based high-throughput method for the identification of protein palmitoylation inhibitors

Open Biology, 2021
Protein S-acylation or palmitoylation is a widespread post-translational modification that consists of the addition of a lipid molecule to cysteine residues of proteins through a thioester bond.
Consuelo Coronel Arrechea, María Luz Giolito, Iris Alejandra García, Gastón Soria, Javier Valdez Taubas   +4 more
doaj   +1 more source

Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

Cell Reports, 2021
Summary: In addition to acetylation, histones are modified by a series of competing longer-chain acylations. Most of these acylation marks are enriched and co-exist with acetylation on active gene regulatory elements.
Mengqing Gao, Jin Wang, Sophie Rousseaux, Minjia Tan, Lulu Pan, Lijun Peng, Sisi Wang, Wenqian Xu, Jiayi Ren, Yuanfang Liu, Martin Spinck, Sophie Barral, Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Denis Puthier, Sandrine Curtet, Lisa Bargier, Zhongyi Cheng, Heinz Neumann, Jian Li, Yingming Zhao, Jian-Qing Mi, Saadi Khochbin   +23 more
doaj   +1 more source

S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels

Frontiers in Physiology, 2014
Mechanisms that control surface expression and/or activity of large conductance calcium-activated potassium (BK) channels are important determinants of their (patho)physiological function.
Michael J Shipston
doaj   +1 more source