Bayesian models and algorithms for protein beta-sheet prediction [PDF]
, 2009 Prediction of the three-dimensional structure greatly benefits from the information related to secondary structure, solvent accessibility, and non-local contacts that stabilize a protein's structure.
Altunbasak, Yucel +5 more
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Sequencing proteins with transverse ionic transport in nanochannels [PDF]
, 2015 {\it De novo} protein sequencing is essential for understanding cellular processes that govern the function of living organisms and all post-translational events and other sequence modifications that occur after a protein has been constructed from its ...
Boynton, P., Di Ventra, M.
core +4 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
BMC Bioinformatics, 2008 Background A number of sequence-based methods exist for protein secondary structure prediction. Protein secondary structures can also be determined experimentally from circular dichroism, and infrared spectroscopic data using empirical analysis methods ...
Lees Jonathan G, Janes Robert W
doaj +1 more source
N-Grams Modeling for Protein Secondary Structure Prediction: Exploring Local Features and Optimal CNN Parameters [PDF]
, 2023 Annisa Rizqiana, Afiahayati
openalex +1 more source
Sequence-Structure Alignment Using a Statistical Analysis of Core Models and Dynamic Programming [PDF]
, 2002 The expanding availability of protein data enforces the application of empirical methods necessary to recognize protein structures. In this paper a sequence-structure alignment method is described and applied to various Ubiquitin-like folded Ras-binding ...
Brunnert, Marcus +2 more
core +1 more source
Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors. [PDF]
, 2017 Aptamers consist of short oligonucleotides that bind specific targets. They provide advantages over antibodies, including robustness, low cost, and reusability.
Jeddi, Iman, Saiz, Leonor
core +2 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Secondary structure predictions for silkmoth chorion proteins
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982 The complete primary structure of many silkmoth chorion proteins is now known. These proteins are products of two major multigene families, A and B. Here we predict the secondary structure of representative A and B chorion proteins, using six different predictive methods. In both families of proteins 0-sheet structure predominates.
HAMODRAKAS, SJ, JONES, CW, KAFATOS, FC
openaire +2 more sources