Results 11 to 20 of about 6,974,231 (359)
Protein secretion and secreted proteins in pathogenicNeisseriaceae [PDF]
FEMS Microbiology Reviews, 2006 Secreted proteins of pathogenic bacteria are often essential virulence factors. They are involved, for example, in the adherence of the bacteria to host cells or required to suppress the host's defence mechanisms. Until recently, only IgA1 protease had been studied in detail in the NeisseriaceaeNeisseria meningitidis and Neisseria gonorrhoeae.
van Ulsen, J.P., Tommassen, J.P.M.
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Regulated Secretion: Helper proteins for neuroendocrine secretion [PDF]
Current Biology, 1995 The granins, known to be general constituents of neuroendocrine secretory granules, are regulators of the proteolytic processing of peptide precursors and promote their aggregation-mediated sorting into secretory granules.
Huttner, Wieland B., Natori, Shoichi
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EMBO Molecular Medicine, 2020 Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi +20 more
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Biomedicines, 2022 The NF-κB system is a key transcriptional pathway that regulates innate and adaptive immunity because it triggers the activation and differentiation processes of lymphocytes and myeloid cells during immune responses.
Jasmin Priester +3 more
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A holin/peptidoglycan hydrolase‐dependent protein secretion system
Molecular Microbiology, 2020 Gram‐negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall‐editing enzyme to mediate the ...
T. Palmer +4 more
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Structures of the Type IX Secretion/Gliding Motility Motor from across the Phylum Bacteroidetes
mBio, 2022 Gliding motility using cell surface adhesins, and export of proteins by the type IX secretion system (T9SS) are two phylum-specific features of the Bacteroidetes.
Rory Hennell James +4 more
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Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase
mBio, 2021 Genetic editing has revolutionized biotechnology, but delivery of endonuclease genes as DNA can lead to aberrant integration or overexpression, leading to off-target effects.
Steven J. Hersch, Linh Lam, Tao G. Dong
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Frontiers in Cellular and Infection Microbiology, 2022 Tannerella forsythia and Porphyromonas gingivalis target distinct virulence factors bearing a structurally conserved C-terminal domain (CTD) to the type IX protein secretion system (T9SS).
Matthias L. Braun +7 more
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Cell Reports, 2022 Summary: Protein machines undergo conformational motions to interact with and manipulate polymeric substrates. The Sec translocase promiscuously recognizes, becomes activated, and secretes >500 non-folded preprotein clients across bacterial cytoplasmic ...
Srinath Krishnamurthy +10 more
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The Plasma Membrane: A Platform for Intra- and Intercellular Redox Signaling
Antioxidants, 2018 Membranes are of outmost importance to allow for specific signal transduction due to their ability to localize, amplify, and direct signals. However, due to the double-edged nature of reactive oxygen species (ROS)—toxic at high concentrations but ...
Daniela E. Nordzieke +1 more
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