Results 151 to 160 of about 6,753,180 (197)
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Current Opinion in Structural Biology, 1996
Protein sequence motifs are signatures of protein families and can often be used as tools for the prediction of protein function. The generalization and modification of already known motifs are becoming major trends in the literature, even though new motifs are still being discovered at an approximately linear rate.
P, Bork, E V, Koonin
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Protein sequence motifs are signatures of protein families and can often be used as tools for the prediction of protein function. The generalization and modification of already known motifs are becoming major trends in the literature, even though new motifs are still being discovered at an approximately linear rate.
P, Bork, E V, Koonin
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Gene Analysis Techniques, 1987
There has been a rapid increase in the number of available protein sequences derived from gene-sequence information. Computer-based sequence analysis of proteins is gaining in importance as an analytical tool. With the help of these analyses such sequences may be characterized and some insights gained into their probable role in the system.
D, Chatterjee, J V, Maizel
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There has been a rapid increase in the number of available protein sequences derived from gene-sequence information. Computer-based sequence analysis of proteins is gaining in importance as an analytical tool. With the help of these analyses such sequences may be characterized and some insights gained into their probable role in the system.
D, Chatterjee, J V, Maizel
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Advances in Protein Sequencing
Annual Review of Biochemistry, 1981Although this review cannot possibly cover the myriad of new ideas reported in the analyses of 1100 proteins, it does attempt to highlight procedures and strategies of interest, admittedly with a bias toward examples most familiar to us. It is clear that the scope, efficiency, and sensitivity of the analyses have increased and will continue to do so ...
K A, Walsh +3 more
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On Compressibility of Protein Sequences
Data Compression Conference (DCC'06), 2006We consider the problem of compressibility of protein sequences. Based on an observed genome-scale long-range correlation in concatenated protein sequences from different organisms, we propose a method to exploit this unusual redundancy in compressing the protein sequences.
Donald A. Adjeroh, Fei Nan
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A unified sequence-structure classification of protein sequences
Proceedings of the fourth annual international conference on Computational molecular biology, 2000We analyze all known protein sequences in search for a global map of protein space that is consistent in terms of both sequence and structure. Our goal is to define clusters of homologous protein domains, beyond those detected by sequence-based methods alone, and then to build a three-dimensional (3D) model for each of the sequences that are homologous
Golan Yona, Michael Levitt 0001
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Visualizing the Protein Sequence Universe
Concurrency and Computation: Practice and Experience, 2012SUMMARYModern biology is experiencing a rapid increase in data volumes that challenges our analytical skills and existing cyberinfrastructure. Exponential expansion of the protein sequence universe (PSU), the protein sequence space, together with the costs and complexities of manual curation creates a major bottleneck in life sciences research ...
Larissa Stanberry +10 more
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Mining Protein Sequences for Motifs
Journal of Computational Biology, 2002We use methods from Data Mining and Knowledge Discovery to design an algorithm for detecting motifs in protein sequences. The algorithm assumes that a motif is constituted by the presence of a "good" combination of residues in appropriate locations of the motif.
Giri Narasimhan +5 more
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2009
Protein sequence databases do not contain just the sequence of the protein itself but also annotation that reflects our knowledge of its function and contributing residues. In this chapter, we will discuss various public protein sequence databases, with a focus on those that are generally applicable.
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Protein sequence databases do not contain just the sequence of the protein itself but also annotation that reflects our knowledge of its function and contributing residues. In this chapter, we will discuss various public protein sequence databases, with a focus on those that are generally applicable.
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2007
Despite significant advances in the identification of known proteins, the analysis of unknown proteins by tandem mass spectrometry (MS/MS) still remains a challenging open problem. Although Klaus Biemann recognized the potential of mass spectrometry for sequencing of unknown proteins in the 1980s, low-throughput Edman degradation followed by cloning ...
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Despite significant advances in the identification of known proteins, the analysis of unknown proteins by tandem mass spectrometry (MS/MS) still remains a challenging open problem. Although Klaus Biemann recognized the potential of mass spectrometry for sequencing of unknown proteins in the 1980s, low-throughput Edman degradation followed by cloning ...
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Compact Protein Sequencer for the C-Terminal Sequence Analysis of Peptides and Proteins
Analytical Biochemistry, 1993We describe the construction of a compact protein sequencer designed specifically for the C-terminal sequence analysis of peptides and proteins. This sequencer has a vertical flow path and is equipped with a continuous flow reactor (CFR). The flow paths for the various reagents and solvents have been minimized.
J M, Bailey, M, Rusnak, J E, Shively
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