Results 131 to 140 of about 3,139,545 (345)
BiomoleculesMultiple sequence alignment (MSA) has evolved into a fundamental tool in the biological sciences, playing a pivotal role in predicting molecular structures and functions.
Chenyue Zhang +6 more
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Identical Sequences, Different Behaviors: Protein Diversity Captured at the Single-Molecule Level [PDF]
, 2021 Rafael Tapia‐Rojo +3 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Sequence Evolution and the Mechanism of Protein Folding [PDF]
, 2000 Ángel R. Ortíz, Jeffrey Skolnick
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Advances in computational protein design: development of more efficient search algorithms and their application to the full-sequence design of larger proteins [PDF]
, 2005 Geoffrey K. Hom
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
A paired sequence language model for protein-protein interaction modeling
Nature CommunicationsUnderstanding protein–protein interactions (PPIs) is crucial for deciphering cellular processes and guiding therapeutic discovery. While recent protein language models have advanced sequence-based protein representation, most are designed for individual ...
Jun Liu, Hungyu Chen, Yang Zhang
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