Results 61 to 70 of about 6,753,180 (197)

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

Identification of Heat-Resistant Bacteria Based on Selection of Proper Representation of Protein Sequences Using Deep Learning Approach

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Identification of effective mechanisms in heat-resistance in bacteria is of great importance in some industries, such as food industry, textile manufacturing, and especially in detergent production industries. For this purpose,
Reza Ahsan, Mansour Ebrahimi
doaj  

Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

eLife, 2019
Diabetes is a diverse and complex disease, with considerable variation in phenotypic manifestation and severity. This variation hampers the study of etiological differences and reduces the statistical power of analyses of associations to genetics ...
Isa Kristina Kirk, Christian Simon, Karina Banasik, Peter Christoffer Holm, Amalie Dahl Haue, Peter Bjødstrup Jensen, Lars Juhl Jensen, Cristina Leal Rodríguez, Mette Krogh Pedersen, Robert Eriksson, Henrik Ullits Andersen, Thomas Almdal, Jette Bork-Jensen, Niels Grarup, Knut Borch-Johnsen, Oluf Pedersen, Flemming Pociot, Torben Hansen, Regine Bergholdt, Peter Rossing, Søren Brunak   +20 more
doaj   +1 more source

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]

, 2011
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela, Tosatto, Silvio C. E., Giorgia Busolin, Simonetta Andreazza, Busolin, Giorgia, Tosatto, Silvio C E, Emanuela Leonardi, Carlo Nobile, Silvio C E Tosatto, TOSATTO, SILVIO, Busolin Giorgia, Silvio C. E. Tosatto, Tosatto Silvio C. E., Vanin, Stefano, Vanin Stefano, NOBILE C, Langowski, Jörg, Stefano Vanin, Andreazza Simonetta, Andreazza, Simonetta, Nobile, Carlo, ANDREAZZA A, Leonardi Emanuela, Nobile Carlo   +23 more
core   +1 more source

Comparing In Silico Fungi Toxicity Prediction with In Vitro Cytotoxicity Assay for Indoor Airborne Fungi

Applied Sciences
Technological advancements have shifted human living and working environments from outdoor to indoor. Although indoor spaces offer protection from unfavorable weather conditions, they also present new health challenges.
Sung-Yoon Ahn, Mira Kim, Hye-Won Jeong, Wonsuck Yoon, Iel-Soo Bang, Sang-Woong Lee   +5 more
doaj   +1 more source

Use of residue pairs in protein sequence‐sequence and sequence‐structure alignments [PDF]

Protein Science, 2000
AbstractTwo new sets of scoring matrices are introduced: H2 for the protein sequence comparison and T2 for the protein sequence–structure correlation. Each element of H2 or T2 measures the frequency with which a pair of amino acid types in one protein, k‐residues apart in the sequence, is aligned with another pair of residues, of given amino acid types
J, Jung, B, Lee
openaire   +2 more sources

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT, Berman, HM, Luscombe, NM, Helen M Berman (10123868), Susan Jones (4079), Thornton, JM, David T A Daley (16115222), Janet M Thornton (16060073), Jones, S, Nicholas M Luscombe (8114756)   +9 more
core  

CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure [PDF]

, 2012
Background: One aim of the in silico characterization of proteins is to identify all residue-positions, which are crucial for function or structure. Several sequence-based algorithms exist, which predict functionally important sites.
Kück, Fabian, Rainer Merkl, Merkl, Rainer, Fabian Kück, Busch, Markus, Porfenenko, Mikhail, Mikhail Porfenenko, Merkl Rainer, Jan-Oliver Janda, Kück Fabian, Janda, Jan-Oliver, Porfenenko Mikhail, Janda Jan-Oliver, Busch Markus, Markus Busch   +14 more
core   +1 more source

Exact correspondence between walk in nucleotide and protein sequence spaces. [PDF]

PLoS ONE, 2017
In the course of evolution, genes traverse the nucleotide sequence space, which translates to a trajectory of changes in the protein sequence in protein sequence space.
Dmitry N Ivankov
doaj   +1 more source

Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments

BMC Bioinformatics, 2010
Background While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor and a similar structure; pairwise sequence alignments often fail to ...
Bass Ellen J, Smoot Michael E, Sierk Michael L, Pearson William R   +3 more
doaj   +1 more source