Results 61 to 70 of about 3,139,545 (345)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
eLife, 2019 Diabetes is a diverse and complex disease, with considerable variation in phenotypic manifestation and severity. This variation hampers the study of etiological differences and reduces the statistical power of analyses of associations to genetics ...
Isa Kristina Kirk +20 more
doaj +1 more source
Fold-specific sequence scoring improves protein sequence matching [PDF]
BMC Bioinformatics, 2016 Abstract Background Sequence matching is extremely important for applications throughout biology, particularly for discovering information such as functional and evolutionary relationships, and also for discriminating between unimportant and disease mutants.
Leelananda, Sumudu +2 more
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
CORRELATED MUTATIONS IN SELECTED PROTEIN FAMILIES
TASK Quarterly, 2002 Four different protein families (two proteinase inhibitor families, myoglobins and lysozymes) were surveyed for correlated mutations with respect to the position distance and their significance in structure stabilization and biological activity.
JACEK LELUK +2 more
doaj
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020 Background and Objectives: Identification of effective mechanisms in heat-resistance in bacteria is of great importance in some industries, such as food industry, textile manufacturing, and especially in detergent production industries. For this purpose,
Reza Ahsan, Mansour Ebrahimi
doaj
Exact correspondence between walk in nucleotide and protein sequence spaces. [PDF]
PLoS ONE, 2017 In the course of evolution, genes traverse the nucleotide sequence space, which translates to a trajectory of changes in the protein sequence in protein sequence space.
Dmitry N Ivankov
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Applied SciencesTechnological advancements have shifted human living and working environments from outdoor to indoor. Although indoor spaces offer protection from unfavorable weather conditions, they also present new health challenges.
Sung-Yoon Ahn +5 more
doaj +1 more source
Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 [PDF]
, 2006 Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection.
Arnold, Frances H. +5 more
core +1 more source