s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin [PDF]
, 1992 Cyclophilins (cyclosporin A-binding proteins) are conserved, ubiquitous, and abundant proteins that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins in vitro.
Arber, S. +6 more
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The sim gene of Escherichia coli phage P1: nucleotide sequence and purification of the processed protein [PDF]
, 1990 Maillou J, Dreiseikelmann B. The sim gene of Escherichia coli phage P1: nucleotide sequence and purification of the processed protein. Virology. 1990;175(2):500-507.The sim gene of bacteriophage P1 causes exclusion of a superinfecting P1 phage.
Maillou, Julia, Dreiseikelmann, Brigitte
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LPBERT: A Protein–Protein Interaction Prediction Method Based on a Pre-Trained Language Model
Applied SciencesThe prediction of protein–protein interactions is a key task in proteomics. Since protein sequences are easily available and understandable, they have become the primary data source for predicting protein–protein interactions.
An Hu, Linai Kuang, Dinghai Yang
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Molecules, 2018 Protein-protein interactions (PPIs) play important roles in various aspects of the structural and functional organization of cells; thus, detecting PPIs is one of the most important issues in current molecular biology.
Tao Wang +5 more
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Primary sequence based protein–protein interaction binder generation with transformers
Complex & Intelligent Systems, 2023 The design of binder proteins for specific target proteins using deep learning is a challenging task that has a wide range of applications in both designing therapeutic antibodies and creating new drugs.
Junzheng Wu +3 more
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Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]
, 1991 Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Reddehase, Matthias J. +9 more
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CORRELATED MUTATIONS IN SELECTED PROTEIN FAMILIES
TASK Quarterly, 2002 Four different protein families (two proteinase inhibitor families, myoglobins and lysozymes) were surveyed for correlated mutations with respect to the position distance and their significance in structure stabilization and biological activity.
JACEK LELUK +2 more
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Discover protein sequence signatures from protein-protein interaction data
BMC Bioinformatics, 2005 Background The development of high-throughput technologies such as yeast two-hybrid systems and mass spectrometry technologies has made it possible to generate large protein-protein interaction (PPI) datasets.
Haasl Ryan J +3 more
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Protein-Protein Interactions Prediction Based on Graph Energy and Protein Sequence Information
Molecules, 2020 Identification of protein-protein interactions (PPIs) plays an essential role in the understanding of protein functions and cellular biological activities. However, the traditional experiment-based methods are time-consuming and laborious.
Da Xu +4 more
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PoET: A generative model of protein families as sequences-of-sequences
Advances in Neural Information Processing Systems 36, 2023 Generative protein language models are a natural way to design new proteins with desired functions. However, current models are either difficult to direct to produce a protein from a specific family of interest, or must be trained on a large multiple sequence alignment (MSA) from the specific family of interest, making them unable to benefit from ...
Timothy F. Truong Jr., Tristan Bepler
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