Results 31 to 40 of about 6,753,180 (197)

Prediction of Protein Function Using Statistically Significant Sub-Structure Discovery [PDF]

, 2007
Proteins perform a vast number of functional roles. The number of protein structures available for analysis continues to grow and, with the development of methods to predict protein structure directly from genetic sequence without imaging technology, the
Lucas, Craig
core   +7 more sources

Sequence Motifs in MADS Transcription Factors Responsible for Specificity and Diversification of Protein-Protein Interaction [PDF]

, 2010
Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins.
Angenent, G.C., Martijn Fiers, Roeland C H J van Ham, Roeland C. H. J. van Ham, Morabito Giuseppa, Ham, R.C.H.J., van, Aalt D J van Dijk, Angenent Gerco C., Immink, R.G.H., van Dijk, A.D.J., Richard G H Immink, van Dijk Aalt D. J., Morabito, G., van Ham Roeland C. H. J., Dijk, A.D.J., van, Fiers, M.A., Richard G. H. Immink, Giuseppa Morabito, van Ham, R.C.H.J., Aalt D. J. van Dijk, Immink Richard G. H., Gerco C Angenent, Gerco C. Angenent, Fiers Martijn   +23 more
core   +2 more sources

SPHot: Prediction of Hot Spots in Protein-RNA Complexes by Protein Sequence Information and Ensemble Classifier

IEEE Access, 2019
RNA-binding hot spots are a small and complementary set of interfacial residues that contribute most to the binding energy of protein-RNA interfaces. As experimental methods for identifying hot spots are time-consuming, labor-intensive and costly, there ...
Sijia Zhang, Le Zhao, Junfeng Xia
doaj   +1 more source

Repeatability in protein sequences

Journal of Structural Biology, 2019
Low complexity regions (LCRs) in protein sequences have special properties that are very different from those of globular proteins. The rules that define secondary structure elements do not apply when the distribution of amino acids becomes biased.
Mohamed Kamel, Pablo Mier, Abdelkamel Tari, Miguel A. Andrade-Navarro   +3 more
openaire   +2 more sources

Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]

, 2009
To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
core   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Why similar protein sequences encode similar three-dimensional structures? [PDF]

, 2010
Evolutionarily related proteins have similar sequences. Such similarity is called homology and can be described using substitution matrices such as Blosum 60.
Zielenkiewicz, Piotr, Kaczanowski, Szymon   +1 more
core   +1 more source

Purification, Characterization, Identification, and Anticancer Activity of a Circular Bacteriocin From Enterococcus thailandicus

Frontiers in Bioengineering and Biotechnology, 2020
New anticancer agents are continually needed because cancerous cells continue to evolve resistance to the currently available chemotherapeutic agents.
Lamiaa A. Al-Madboly, Nehal M. El-Deeb, Amal Kabbash, Manal A. Nael, Ahmed M. Kenawy, Amany E. Ragab   +5 more
doaj   +1 more source

An assessment of feature relevance in predicting protein function from sequence [PDF]

, 2004
Improving the performance of protein function prediction is the ultimate goal for a bioinformatician working in functional genomics. The classical prediction approach is to employ pairwise sequence alignments. However this method often faces difficulties
Tan, AC, Al-Shahib, A, Tan, A.C., Gilbert, D, Gilbert, D.G., Aik Choon Tan, Chao He, Al-Shahib, Ali, Girolami, M, Mark Girolami, David Gilbert, Gilbert, M, ,, Girolami, M., He, C, Ali Al-shahib, He, C., Al-Shahib, A.   +17 more
core   +1 more source

PROTEIN IDENTIFICATION USING SEQUENCE DATABASES

Scientific Journal of Astana IT University, 2020
The bottom-up proteomics approach (also known as the shotgun approach), based on the digestion of proteins in peptides and their sequencing using tandem mass spectrometry (MS/MS), has become widespread.
Ye. Golenko, A. Ismailova, Ye. Rais
doaj   +3 more sources