Domain discovery method for topological profile searches in protein structures [PDF]
, 2004 We describe a method for automated domain discovery for topological profile searches in protein structures. The method is used in a system TOPStructure for fast prediction of CATH classification for protein structures (given as PDB files).
Viksna, J, Gilbert, D, Torrance, G
core +6 more sources
Pattern matching and pattern discovery algorithms for protein topologies [PDF]
, 2001 We describe algorithms for pattern matching and pattern learning in TOPS diagrams (formal descriptions of protein topologies). These problems can be reduced to checking for subgraph isomorphism and finding maximal common subgraphs in a restricted ...
Viksna, J +3 more
core +7 more sources
Prediction of Protein Function Using Statistically Significant Sub-Structure Discovery [PDF]
, 2007 Proteins perform a vast number of functional roles. The number of protein structures available for analysis continues to grow and, with the development of methods to predict protein structure directly from genetic sequence without imaging technology, the
Lucas, Craig
core +7 more sources
Foods, 2023 It is essential to understand the mechanism of action of ultrasound synergistic free radical oxidation to promote covalent reactions between proteins and polyphenols.
Jiaxing Cao +4 more
doaj +1 more source
On the molecular mechanisms of mitotic kinase activation [PDF]
Open Biology, 2012 During mitosis, human cells exhibit a peak of protein phosphorylation that alters the behaviour of a significant proportion of proteins, driving a dramatic transformation in the cell's shape, intracellular structures and biochemistry.
Richard Bayliss +3 more
doaj +1 more source
In situ high-resolution structure of the baseplate antenna complex in Chlorobaculum tepidum
Nature Communications, 2016 The chlorosome of the photosynthetic bacterium C. tepidumharvests light and transfers the energy to the photosynthetic reaction centre. Here the authors determine the structure of the baseplate, a scaffolding super-structure, to show that the baseplate ...
Jakob Toudahl Nielsen +13 more
doaj +1 more source
Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution
Nature Communications, 2019 It remains a challenge to obtain high-resolution structures of molecules smaller than 200 kDa using single particle cryo-EM. Here, the authors apply the Cs-corrector-VPP coupled cryo-EM and solve structures of the 52 kDa streptavidin (SA) protein at near-
Xiao Fan +8 more
doaj +1 more source
Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX
IUCrJ, 2022 CmABCB1 is a Cyanidioschyzon merolae homolog of human ABCB1, a well known ATP-binding cassette (ABC) transporter responsible for multi-drug resistance in various cancers.
Dongqing Pan +11 more
doaj +1 more source
Why similar protein sequences encode similar three-dimensional structures? [PDF]
, 2010 Evolutionarily related proteins have similar sequences. Such similarity is called homology and can be described using substitution matrices such as Blosum 60.
Zielenkiewicz, Piotr +1 more
core +1 more source
Generation and Application of Fluorescent Anti-Human β2-Microglobulin VHHs via Amino Modification
Molecules, 2019 The functionalization of VHHs enables their application in almost every aspect of biomedical inquiry. Amino modification remains a common strategy for protein functionalization, though is considered to be inferior to site-specific methods and cause ...
Chundong Huang +4 more
doaj +1 more source