A structural alignment kernel for protein structures [PDF]
Bioinformatics, 2007 AbstractMotivation: This work aims to develop computational methods to annotate protein structures in an automated fashion. We employ a support vector machine (SVM) classifier to map from a given class of structures to their corresponding structural (SCOP) or functional (Gene Ontology) annotation.
Jian Qiu +4 more
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Modeling of tertiary and quaternary protein structures by homology [PDF]
, 2012 The structure of a protein is crucial to understand its function. Despite this importance, experimentally solved structures are only available for a small portion of the currently known protein sequences.
Kiefer, Florian
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The CATH database: an extended protein family resource for structural and functional genomics [PDF]
, 2003 The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath_new) currently contains 34 287 domain structures classified into 1383 superfamilies and 3285 sequence families.
Pearl, F.M.G. +8 more
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Analysis of Protein Disorder Predictions in the Light of a Protein Structural Alphabet
Biomolecules, 2020 Intrinsically-disordered protein (IDP) characterization was an amazing change of paradigm in our classical sequence-structure-function theory. Moreover, IDPs are over-represented in major disease pathways and are now often targeted using small molecules ...
Alexandre G. de Brevern
doaj +1 more source
Objective identification of residue ranges for the superposition of protein structures [PDF]
, 2011 Background: The automation of objectively selecting amino acid residue ranges for structure superpositions is important for meaningful and consistent protein structure analyses.
Kirchner Donata K +5 more
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Structural Proteins of Reoviruses [PDF]
Journal of Virology, 1968 Polyacrylamide gel electrophoresis of the solubilized proteins from the three serotypes of reovirus revealed that each contained three major and four minor components. Subviral particles were prepared by brief treatment of complete virions with urea.
P C, Loh, A J, Shatkin
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CATHEDRAL: A fast and effective algorithm to predict folds and domain boundaries from multidomain protein structures [PDF]
, 2007 We present CATHEDRAL, an iterative protocol for determining the location of previously observed protein folds in novel multidomain protein structures. CATHEDRAL builds on the features of a fast secondary-structure-based method ( using graph theory) to ...
Oliver C Redfern +22 more
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Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
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Protein structure prediction [PDF]
International Journal of Modern Physics B, 2018 Predicting 3D structure of protein from its amino acid sequence is one of the most important unsolved problems in biophysics and computational biology. This paper attempts to give a comprehensive introduction of the most recent effort and progress on protein structure prediction.
Haiyou, Deng, Ya, Jia, Yang, Zhang
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Structural dissection of two redox proteins from the shipworm symbiont Teredinibacter turnerae
IUCrJThe discovery of lytic polysaccharide monooxygenases (LPMOs), a family of copper-dependent enzymes that play a major role in polysaccharide degradation, has revealed the importance of oxidoreductases in the biological utilization of biomass.
Badri S. Rajagopal +13 more
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