Results 101 to 110 of about 1,981,418 (307)

Calcium signalling links MYC to NUAK1 [PDF]

, 2018
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A,, Knight, J.R., Monteverde, T., Murphy, D.J., Sansom, O.J., Tait-Mulder, J.   +5 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Gidijala, Loknath,, Kiel, Jan A.K.W.,, Klei, Ida J. van der,, Veenhuis, Marten,   +3 more
core   +2 more sources

To Decipher the Mycoplasma hominis Proteins Targeting into the Endoplasmic Reticulum and Their Implications in Prostate Cancer Etiology Using Next-Generation Sequencing Data

Molecules, 2018
Cancer was initially considered a genetic disease. However, recent studies have revealed the connection between bacterial infections and growth of different types of cancer.
Mohammed Zakariah, Shahanavaj Khan, Anis Ahmad Chaudhary, Christian Rolfo, Mohamed Maher Ben Ismail, Yousef Ajami Alotaibi   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. [PDF]

, 2017
Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote ...
Cao, Ke, Chen, Jia, Chen, Xiang, Chen, Yao, Chen, Yong, Cheng, Yan, Li, Jingjing, Qian, Li, Tang, Jintian, Tang, Shijie, Wang, Aijun, Xiong, Wei, Zhou, Jianda   +12 more
core   +1 more source

Paulinella chromatophora – rethinking the transition from endosymbiont to organelle

Acta Societatis Botanicorum Poloniae, 2014
Eukaryotes co-opted photosynthetic carbon fixation from prokaryotes by engulfing a cyanobacterium and stably integrating it as a photosynthetic organelle (plastid) in a process known as primary endosymbiosis.
Eva C.M. Nowack
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

How finicky is mitochondrial protein import? [PDF]

, 1988
Recently it was reported that artificial targeting signals or signals specific for organelles other than mitochondria could direct proteins into mitochondria.
Allison, Baker, Banroques, Bedwell, Boutry, Eilers, Hurt, Hurt, Hurt, Ohba, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Roise, Schleyer, Vassarotti, von Heijne, Zwizinski   +20 more
core   +1 more source

The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein

Cell Death and Disease
Triple-negative breast cancer (TNBC) is an aggressive subtype of invasive breast cancer characterized by limited treatment options and a poor prognosis. While ferroptosis, an iron-dependent form of regulated cell death, plays a role in tumor suppression,
Li Yang, Xiaoqin An, Shangzhu Yang, Xiaowen Lin, Ziyuan Chen, Qian Xue, Xi Chen, Yuan Wang, Ding Yan, Shirui Chen, Yuqing Fan, Daolin Tang, Wenfeng Yu, Jinbao Liu, Xin Chen   +14 more
doaj   +1 more source