Results 121 to 130 of about 1,447,276 (313)

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum [PDF]

, 2007
Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Ryan Bissett, Carsten Wrenger, Gunther, M, Storm Janet, McMillan, Paul, Günther, S, Müller, S, Wallace, L., Muller, S., Patzewitz, Eva-Maria, Paul J McMillan, Lynsey Wallace, Wrenger, C., Günther, S., Bissett Ryan, Wrenger, Carsten, Smith, T.K., Muller, Sylke, McMillan Paul J, Bissett, Ryan, Guenther, Svenja, McMillan, Paul J., Smith, Terry, Sylke Müller, Patzewitz, E.-M., Terry K Smith, Storm, J., Günther Svenja, Storm, Janet, Svenja Günther, Patzewitz, EM, Wallace, Lynsey, Storm, J, McMillan, PJ, Patzewitz Eva-Maria, Mueller, Sylke, McMillan, P.J., Eva-Maria Patzewitz, Wallace Lynsey, Bissett, R, Wrenger, C, Janet Storm, Smith Terry K, Smith, TK, Wrenger Carsten, Smith, Terry K, Wallace, L, Bissett, R., Müller Sylke   +48 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Multi-state Targeting Machinery Govern the Fidelity and Efficiency of Protein Localization

, 2014
Proper localization of newly synthesized proteins is essential to cellular function. Among different protein localization modes, the signal recognition particle (SRP) and SRP receptor (SR) constitute the conserved targeting machinery in all three life ...
Han, KL, Pang, Xueqin, Yang, MJ, Han, Keli, Yang, Mingjun, Zhang, X   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Intracellular CXCR4+ cell targeting with T22-empowered protein-only nanoparticles

, 2012
Ugutz Unzueta,1–3 María Virtudes Céspedes,3,4 Neus Ferrer-Miralles,1–3 Isolda Casanova,3,4 Juan Cedano,5 José Luis Corchero,1–3 Joan Domingo-Espín,1–3 Antonio Villaverde ...
Corchero JL, Mangues R, Villaverde A, Vázquez E, Casanova I, Céspedes MV, Ferrer-Miralles N, Cedano J, Domingo-Espín J, Unzueta U   +9 more
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Computational approaches for drug design at the Protein-Protein interface [PDF]

, 2010
The ability to design drugs that disrupt formation of protein-protein interfaces is of particular interest to the pharmaceutical industry due to its promise for opening an entire new range of drug targets, many of which have already been well ...
Fuller, Jonathan Christopher
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source