Results 81 to 90 of about 1,447,276 (313)

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1(MCL1)

, 2019
Here we show the development of heterobifunctional small molecules capable of selectively targeting MCL1 using a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the
Ranjan, Maity, James, Papatzimas, Paola, Neri, Nizar J., Bahlis, Evgueni, Gorobets, Justin L., MacCallum, Darren, Derksen, Mir Ishruna, Muniyat   +7 more
core   +1 more source

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]

, 2014
E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Dias, David M, Carles Galdeano (1305135), Galdeano, Carles, Dias, David M., David M. Dias (1340694), Van Molle, Inge, Gadd, Morgan Stuart, Ciulli, Alessio, Sarah Hewitt (1340700), Soares, Pedro, Galdeano , Carles, Pedro Soares (393566), Gadd, Morgan S., Salvatore Scaffidi (1340703), Inge Van Molle (1284120), Morgan S. Gadd (149371), Scaffidi, Salvatore, Ipek Birced (1340697), Alessio Ciulli (762789), Hewitt, Sarah, Birced, Ipek   +20 more
core   +1 more source

Specific and efficient targeting of cyanobacterial bicarbonate transporters to the inner envelope membrane of chloroplasts in Arabidopsis

Frontiers in Plant Science, 2016
Installation of cyanobacterial bicarbonate transporters to the inner envelope membrane (IEM) of chloroplasts in C3 plants has been thought to improve photosynthetic performance.
Susumu eUehara, Fumi eAdachi, Yasuko eIto-Inaba, Takehito eInaba   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Collagen targeting using multivalent protein-functionalized dendrimers

, 2011
Collagen is an attractive marker for tissue remodeling in a variety of common disease processes. Here we report the preparation of protein dendrimers as multivalent collagen targeting ligands by native chemical ligation of the collagen binding protein ...
Lempens, E.H.M., Temming, R.P., Merkx, M., Breurken, M., Meijer, E.W., Helms, B.A.   +5 more
core   +1 more source

A Novel Approach to Relocate Misplaced Proteins in Cells

Biology
Proper cellular function hinges on appropriate subcellular protein localization. When cellular proteins become mislocalized, they can accumulate, cause cellular damage, and disrupt many biochemical and cellular processes.
Grace Hohman, Ava Watson, Mohamed A. Eldeeb   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Protein-protein interaction profile of the CIA targeting complex.

, 2018
(A)-(D) Tandem affinity purification from WT parasites (mock) or PTP-tagged CIA components. Eluates were resolved in Bis-Tris gels and sections were analysed by mass spectrometry for protein identification.
Maiko Luis Tonini (5879708), Antonio J. Pierik (198528), Roland Lill (2369986), Alexander C. Haindrich (3613223), Eva Kriegová (5146508), Stuart A. MacNeill (5879714), Julius Lukeš (122896), Somsuvro Basu (5879711), Terry K. Smith (112550), Priscila Peña-Diaz (3913348)   +9 more
core   +1 more source

The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX [PDF]

, 2009
A plastid-like organelle, the apicoplast, is essential to the majority of medically and veterinary important apicomplexan protozoa including Toxoplasma gondii and Plasmodium.
Chen, C-Y., Henriquez, F L, Roberts, C. W., Chen, C.Y., Barrett, M.P., Chen, C-Y, Barrett, M. P., Roberts, C W, Henriquez, F. L., Doerig, C., Roberts, C.W., Roberts, Craig, Mukhopadhyay, A, Chen, C.-Y., Mukhopadhyay, A., Henriquez, F.L., Barrett, M P, Doerig, C   +17 more
core   +1 more source

Targeting and Assembly of Components of the TOC Protein Import Complex at the Chloroplast Outer Envelope Membrane

Frontiers in Plant Science, 2014
The translocon at the outer envelope membrane of chloroplasts (TOC) initiates the import of thousands of nuclear encoded preproteins required for chloroplast biogenesis and function. The multimeric TOC complex contains two GTP-regulated receptors, Toc34
Lynn G.L. Richardson, Yamuna D Paila, Steven eSiman, Chen eYi, Matthew D Smith, Danny eSchnell   +5 more
doaj   +1 more source