Results 91 to 100 of about 746,971 (308)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The F plasmid conjutome: the repertoire of E. coli proteins translocated through an F-encoded type IV secretion system

mSphere
Bacterial conjugation systems pose a major threat to human health through their widespread dissemination of mobile genetic elements (MGEs) carrying cargoes of antibiotic resistance genes.
Abu Amar M. Al Mamun, Kimberley Kissoon, Yang Grace Li, Erin Hancock, Peter J. Christie   +4 more
doaj   +1 more source

Structural insights into the mechanism of a novel protein targeting pathway in Gram‐negative bacteria

FEBS Open Bio, 2020
Many nascent polypeptides synthesized in the cytoplasm are translocated across membranes via a specific ‘translocon’ composed of protein complexes. Recently, a novel targeting pathway for the outer membrane β‐barrel proteins (OMPs) in Gram‐negative ...
Feng Jin
doaj   +1 more source

Motion of rotatory molecular motor and chemical reaction rate

, 2003
We examine the dependence of the physical quantities of the rotatory molecular motor, such as the rotation velocity and the proton translocation rate, on the chemical reaction rate using the model based only on diffusion process.
D. Stock, D. Subbert, F. Jülicher, H. Noji, H. Wang, Hiroshi Miki, J.P. Abrahams, K. Sekimoto, M.L. Hutcheon, Mahito Kohmoto, Masatoshi Sato, P.D. Boyer, P.D. Boyer, R.D. Vale, R.L. Cross, S.B. Vik, S.P. Tsunoda, T. Elston, T. Matsui, T.M. Duncan, V.K. Rastogi, W. Junge, Y. Sambongi, Y. Zhou   +23 more
core   +1 more source

Transport of proteins into mitochondria [PDF]

, 1985
Translocational intermediates of precursor proteins of ATPase F1β subunit and cytochrome c1 across mitochondrial membranes were analyzed using two different approaches, transport at low temperature and transport after binding of precursor proteins to ...
Neupert, Walter, Schleyer, Manfred
core   +1 more source

Lost in translocation: the functions of the 18-kD translocator protein [PDF]

Trends in Endocrinology & Metabolism, 2015
Research spanning nearly four decades has assigned to the translocator protein (18 kDa) (TSPO) a critical role, among others, in the mitochondrial import of cholesterol, the subsequent steps of (neuro)steroid production, and systemic endocrine regulation, with implications for the pathophysiology of immune, inflammatory, neurodegenerative, and ...
Gut, P, Zweckstetter, M, Banati, RB
openaire   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition

Frontiers in Microbiology, 2019
Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through both inner and outer membranes ...
Fernando Navarro-Garcia, Fernando Ruiz-Perez, Ángel Cataldi, Mariano Larzábal   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. [PDF]

, 2014
Insulin-stimulated glucose uptake in fat and muscle is mediated by the major facilitative glucose transporter Glut4. Insulin controls the trafficking of Glut4 to the plasma membrane via regulation of a series of small G proteins, including RalA and Rab10.
Chen, Xiao-Wei, Karunanithi, Sheelarani, Leto, Dara, Saltiel, Alan R, Sun, Jingxia, Uhm, Maeran, Xiong, Tingting   +6 more
core   +1 more source