Results 21 to 30 of about 16,522,946 (324)

Camostat Does Not Inhibit the Proteolytic Activity of Neutrophil Serine Proteases

Pharmaceuticals, 2022
Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by comorbidities and age. Binding of the severe acute respiratory syndrome coronavirus 2 spike protein (SARS-CoV-2 S protein) to angiotensin-converting enzyme 2 (ACE2), along ...
Akmaral Assylbekova, Anuar Zhanapiya, Renata Grzywa, Marcin Sienczyk, Christian Schönbach, Timo Burster   +5 more
doaj   +1 more source

Upper respiratory tract manifestations in patients with ANCA-associated vasculitides and their association with the presence and type of ANCA

Научно-практическая ревматология, 2021
Aim of the work – to compare the frequency of upper respiratory tract (URT) involvement in patients with ANCAassociated vasculitides (AAV), to reveal its main clinical and radiological patterns and to estimate their association with the serological ...
I. G. Smirnova, N. M. Bulanov, P. I. Novikov, I. A. Osipova, S. V. Moiseev   +4 more
doaj   +1 more source

ANCA Testing in Clinical Practice: From Implementation to Quality Control and Harmonization

Frontiers in Immunology, 2021
Analyses for the presence of anti-neutrophil cytoplasmic antibodies (ANCA) are important in the diagnostic work-up of patients with small vessel vasculitis.
Jan Damoiseaux
doaj   +1 more source

Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1

Molecules, 2022
The prevalence of novel SARS-CoV-2 variants is also accompanied by an increased turnover rate and additional cleavage sites at the positions necessary for priming the Spike (S) protein.
Nadine Anna Schilling, Hubert Kalbacher, Timo Burster   +2 more
doaj   +1 more source

4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis

Frontiers in Immunology, 2020
Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase.
Jérôme Granel, Jérôme Granel, Roxane Lemoine, Eric Morello, Yann Gallais, Julie Mariot, Marion Drapeau, Astrid Musnier, Anne Poupon, Martine Pugnière, Seda Seren, Seda Seren, Dalila Nouar, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart, Hervé Watier, Hervé Watier, Brice Korkmaz, Brice Korkmaz, Cyrille Hoarau, Cyrille Hoarau   +20 more
doaj   +1 more source

Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes

Molecular Medicine, 2019
Non-alcoholic fatty liver disease (NAFLD) is becoming a major health problem worldwide. Inflammation plays an important role in disease pathogenesis and recent studies have shown a potential role for the neutrophil serine proteases (NSPs) proteinase-3 ...
Andreea-Manuela Mirea, E. Toonen, I. V. D. van den Munckhof, I. Munsterman, E. Tjwa, M. Jaeger, M. Oosting, K. Schraa, J. Rutten, M. van der Graaf, N. Riksen, J. de Graaf, M. Netea, C. Tack, T. Chavakis, L. Joosten   +15 more
semanticscholar   +1 more source

Measuring Circulating Complement Activation Products in Myeloperoxidase– and Proteinase 3–Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Arthritis & Rheumatology, 2019
There is accumulating evidence that complement activation is important in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) pathogenesis. This study was undertaken to investigate complement activation in AAV with myeloperoxidase (MPO)
Eveline Y. Wu, E. McInnis, Sonia Boyer-Suavet, Carmen E. Mendoza, Lydia T. Aybar, Kristin B Kennedy, Caroline Poulton, Candace D. Henderson, Yichun Hu, Susan L. Hogan, P. Hu, Hong Xiao, P. Nachman, J. Jennette, Ronald J. Falk, Donna O'Dell Bunch   +15 more
semanticscholar   +1 more source

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Frontiers in Chemistry, 2021
During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications,
Timo Burster, Zhadyra Mustafa, Dinara Myrzakhmetova, Anuar Zhanapiya, Michal Zimecki   +4 more
doaj   +1 more source

Antineutrophil cytoplasmic antibodies

Reumatismo, 2011
Antineutrophil cytoplasmic antibodies (ANCA) are predominantly IgG autoantibodies directed against constituents of primary granules of neutrophils and monocytes’ lysosomes.
G.D. Sebastiani
doaj   +1 more source

Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells

Frontiers in Immunology, 2018
Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs).
Pascale Tacnet-Delorme, Julie Gabillet, Julie Gabillet, Julie Gabillet, Simon Chatfield, Simon Chatfield, Simon Chatfield, Simon Chatfield, Nathalie Thieblemont, Nathalie Thieblemont, Nathalie Thieblemont, Nathalie Thieblemont, Philippe Frachet, Véronique Witko-Sarsat, Véronique Witko-Sarsat, Véronique Witko-Sarsat, Véronique Witko-Sarsat   +16 more
doaj   +1 more source