Results 21 to 30 of about 409,825 (329)

Type of ANCA May Be Indispensable in Distinguishing Subphenotypes of Different Clinical Entities in ANCA-Associated Vasculitis

Life, 2022
The traditional nomenclature system for classifying antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) based on clinical phenotype describes granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA)
Afroditi Maria Konstantouli, Georgios Lioulios, Stamatia Stai, Eleni Moysidou, Asimina Fylaktou, Aikaterini Papagianni, Maria Stangou   +6 more
doaj   +1 more source

Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?

International Journal of Implant Dentistry, 2020
Background Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to
Oya Turkoglu, Candan Efeoglu, Harika Atmaca   +2 more
doaj   +1 more source

Microscopic polyangiitis: Modern concepts and treatment options

Научно-практическая ревматология, 2021
The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation ...
I. T. Murkamilov, K. A. Aitbaev, V. V. Fomin, I. O. Kudaibergenova, F. A. Yusupov, Zh. A. Murkamilova, T. V. Beketova   +6 more
doaj   +1 more source

Proteinase 3 associated with Wegener's granulomatosis [PDF]

Cell Biology International, 2022
AbstractWegener's granulomatosis (WG) is a form of systemic vasculitis characterized by granulomatous inflammation of the upper and lower airways, vasculitis, and necrotizing glomerulonephritis. It is strongly associated with anti‐neutrophil cytoplasmic antibodies against proteinase 3 (PR3‐ANCAs).
openaire   +2 more sources

The major transcriptional regulatory protein of herpes simplex virus type 1 includes a protease resistant DNA binding domain [PDF]

, 1990
Herpes simplex virus type 1 expresses five immediateearly (IE) polypeptides. In the absence of functional Vmw175 (the product of IE gene 3) activation of transcription of later classes of viral genes and repression of IE gene expression does not occur ...
Elliott, M., Everett, R.D., Paterson, T.
core   +2 more sources

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Frontiers in Chemistry, 2021
During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications,
Timo Burster, Zhadyra Mustafa, Dinara Myrzakhmetova, Anuar Zhanapiya, Michal Zimecki   +4 more
doaj   +1 more source

Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria

Haematologica, 2011
Background A deficiency of specific glycosylphosphatidyl inositol-anchored proteins in paroxysmal nocturnal hemoglobinuria may be responsible for most of the clinical features of this disease, but some functional consequences may be indirect. For example,
Anna M. Jankowska, Hadrian Szpurka, Mark Calabro, Sanjay Mohan, Andrew E. Schade, Michael Clemente, Roy L. Silverstein, Jaroslaw P. Maciejewski   +7 more
doaj   +1 more source

Transport of Proteins into Mitochondria [PDF]

, 1980
The mitochondrial ADP/ATP carrier is an integral transmembrane protein of the inner membrane. It is synthesized on cytoplasmic ribosomes. Kinetic data suggested that this protein is transferred into mitochondria in a posttranslational manner.
Allen E. H., Brdiezka D., Chang C. N., Chang C. N., Conboy J. G., Cote C., Date T., Dobberstein B., Flavell R. B., Habermann E., Hackenberg H., Hallermayer G., Harmey M. A., Highfield P. E., Ito K., Klingenberg M., Knoppel E., Korb H., Kreil G., Laemmli U. K., Maccechini M. L., Maccechini M.-L., Mandel G., Marra E., Michel R., Milstein C., Mori M., Nelson N., Pelham H. R. B., Poyton R. O., Poyton R. O., Raymond Y., Schatz G., Sessa G., Shore G. S., Strauss A. W., Vignais P. V., Wickner W., Wickner W., Williams J. C., Zimmermann R., Zimmermann R.   +41 more
core   +1 more source

4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis

Frontiers in Immunology, 2020
Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase.
Jérôme Granel, Jérôme Granel, Roxane Lemoine, Eric Morello, Yann Gallais, Julie Mariot, Marion Drapeau, Astrid Musnier, Anne Poupon, Martine Pugnière, Seda Seren, Seda Seren, Dalila Nouar, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart, Hervé Watier, Hervé Watier, Brice Korkmaz, Brice Korkmaz, Cyrille Hoarau, Cyrille Hoarau   +20 more
doaj   +1 more source

Journal Staff [PDF]

, 1966
Adenovirus encodes for the pVII protein, which interacts and modulates virus DNA structure in the infected cells. The pVII protein is synthesized as the precursor protein and undergoes proteolytic processing by viral proteinase Avp, leading to release of
Inturi, Raviteja, Punga, Tanel, Thaduri, Srinivas   +2 more
core   +5 more sources