Results 31 to 40 of about 18,213,481 (205)

The Proteolytic Activity of Neutrophil-Derived Serine Proteases Bound to the Cell Surface Arming Lung Epithelial Cells for Viral Defense

Molecules
The collaboration between cellular proteases and host cells is pivotal in mounting an effective innate immune defense. Of particular interest is the synergistic interaction between cathepsin G (CatG) and neutrophil elastase (NE), which are proteases ...
Akmaral Assylbekova, Maiya Allayarova, Moldir Konysbekova, Amanbek Bekturgan, Aiya Makhanova, Samantha Brown, Norbert Grzegorzek, Hubert Kalbacher, Ruslan Kalendar, Timo Burster   +9 more
doaj   +1 more source

Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides [PDF]

Терапевтический архив, 2018
Objective. To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA). Materials and methods.
N M Bulanov, E A Makarov, E M Shchegoleva, A S Zykova, E S Vinogradova, P I Novikov, L V Lysenko(Kozlovskaya), S V Moiseev   +7 more
doaj   +1 more source

S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies

Frontiers in Pediatrics, 2018
Objectives: Chronic primary systemic vasculitidies (CPV) are a collection of rare diseases involving inflammation in blood vessels, often in multiple organs. CPV can affect adults and children and may be life- or organ-threatening.
Kelly L. Brown, Kelly L. Brown, Joanna M. Lubieniecka, Giulia Armaroli, Katharina Kessel, Kristen M. Gibson, Kristen M. Gibson, Jinko Graham, Dongmeng Liu, Robert E. W. Hancock, Robert E. W. Hancock, Colin J. Ross, Colin J. Ross, Susanne M. Benseler, Raashid A. Luqmani, David A. Cabral, David A. Cabral, Dirk Foell, Christoph Kessel   +18 more
doaj   +1 more source

Orbital apex schwannoma with a high titer of proteinase 3 antineutrophil cytoplasmic antibody

Radiology Case Reports, 2022
Here, we present a very unusual case of orbital apex schwannoma with a high titer of proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA). A 67-year-old man presented with a 3-month history of double vision.
Tatsushi Oura, MD, Taro Shimono, MD, PhD, Maciej Pas, MD, PhD, Hirotaka Takita, MD, Daisuke Horiuchi, MD, Yasuhito Mitsuyama, MD, Yukio Miki, MD, PhD   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.

, 2004
Antineutrophil cytoplasmic autoantibodies (ANCAs) recognizing human proteinase 3 of neutrophil granules are a diagnostic hallmark of Wegener granulomatosis, an autoimmune systemic vasculitis with predilection for the respiratory tract and kidneys.
Pfister, H;Ollert, M;Fröhlich, LF;Quintanilla-Martinez, L;Colby, TV;Specks, U;Jenne, DE
core   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3—Three Elastases With Similar Primary but Different Extended Specificities and Stability

Frontiers in Immunology, 2018
Serine proteases are major granule constituents of several of the human hematopoietic cell lineages. Four proteolytically active such proteases have been identified in human neutrophils: cathepsin G (hCG), N-elastase (hNE), proteinase 3 (hPR-3), and ...
Zhirong Fu, Michael Thorpe, Srinivas Akula, Gurdeep Chahal, Lars T. Hellman   +4 more
doaj   +1 more source