Results 21 to 30 of about 18,213,481 (205)

A specific proteinase 3 activity footprint in α1-antitrypsin deficiency

ERJ Open Research, 2019
α1-Antitrypsin (α1-AT) deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase (NE) has long been considered the enzyme responsible.
Paul R. Newby, Diana Crossley, Helena Crisford, James A. Stockley, Richard A. Mumford, Richard I. Carter, Charlotte E. Bolton, Nicholas S. Hopkinson, Ravi Mahadeva, Michael C. Steiner, Tom M.A. Wilkinson, Elizabeth Sapey, Robert A. Stockley   +12 more
doaj   +1 more source

ANCA Testing in Clinical Practice: From Implementation to Quality Control and Harmonization

Frontiers in Immunology, 2021
Analyses for the presence of anti-neutrophil cytoplasmic antibodies (ANCA) are important in the diagnostic work-up of patients with small vessel vasculitis.
Jan Damoiseaux
doaj   +1 more source

A neutron laue diffraction study of endothiapepsin: Implications for the aspartic proteinase mechanism [PDF]

, 2001
Current proposals for the catalytic mechanism of aspartic proteinases are largely based on X-ray structures of bound oligopeptide inhibitors possessing nonhydrolyzable analogues of the scissile peptide bond.
Myles, D. A. A., Erskine, P. T., Wood, S. P., L. Coates, Erskine, P.T., Wood, S.P., P. T. Erskine, Cooper, J. B., D. A. A. Myles, Coates, L., S. P. Wood, J. B. Cooper, Cooper, J.B., Myles, D.A.A.   +13 more
core   +1 more source

Investigating Polypharmacology Through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3 [PDF]

, 2023
Using a combination of state-of-the-art free energy computational approaches together with in vitro IC50 assays, we evaluated the polypharmacological potential of a scaffold currently in clinical trials for inhibition of human neutrophil elastase (HNE ...
Fahimeh, Khorsand, Luis F, Cervantes, Ruth, Brenk, Juha Ilmari, Vahokovski, Nathalie, Reuter, Parveen, Gartan, Charles L., Brooks, Pushpak, Mizar, Bengt Erik, Haug   +8 more
core   +2 more sources

Case Report: Proteinase 3 Antineutrophil Cytoplasmic Antibody-Associated Ulcerative Colitis Presenting as Recurrent Intestinal Pseudo-Obstruction in a Teenage Patient With in situ Proteinase 3 Immunohistochemical Staining

Frontiers in Pediatrics, 2022
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with the colorectum as its major target organ. Involvement of the upper gastrointestinal tract in UC is rare and presents with nonspecific endoscopic and microscopic ...
Ching-Wen Yang, Ching-Wen Yang, Yu-Chien Kao, Pei-Chun Lin, Hsi-Yuan Chien, Hsi-Yuan Chien, Sheng-Chieh Lin, Sheng-Chieh Lin, Yu-Hsien Lee, Yen-Lin Huang, Shiuh-Bin Fang, Shiuh-Bin Fang, Shiuh-Bin Fang   +12 more
doaj   +1 more source

Galectin-1 Facilitates Macrophage Reprogramming and Resolution of Inflammation Through IFN-β

Frontiers in Pharmacology, 2020
During the resolution of acute inflammation, macrophages undergo reprogramming from pro-inflammatory, to anti-inflammatory/reparative, and eventually to pro-resolving macrophages. Galectin-1 (Gal-1) is a bona fide pro-resolving lectin while interferon β (
Hiba Yaseen, Sergei Butenko, Irina Polishuk-Zotkin, Sagie Schif-Zuck, Juan Manuel Pérez-Sáez, Gabriel Adrian Rabinovich, Gabriel Adrian Rabinovich, Amiram Ariel   +7 more
doaj   +1 more source

Proteinase 3-antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis complicated by infectious endocarditis: a case report

Journal of Medical Case Reports, 2019
Background Proteinase 3-antineutrophil cytoplasmic antibody has been reported to be positive in 5–10% of cases of renal injury complicated by infective endocarditis; however, histological findings have rarely been reported for these cases.
Katsunori Yanai, Yoshio Kaku, Keiji Hirai, Shohei Kaneko, Saori Minato, Yuko Mutsuyoshi, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Masahiro Hiruta, Susumu Ookawara, Yoshihiko Ueda, Yoshiyuki Morishita   +15 more
doaj   +1 more source

Substrate and inhibitor studies on proteinase 3 [PDF]

, 1992
Various amino acid and peptide thioesters were tested as substrates for human proteinase 3 and the best substrate is Boc-Ala-Ala-Nva-SBzl with a kcal/Km value of 1.0 × 106nMit-1sit-1 Boc-Ala-Ala-AA-SBzl (AA = Val, Ala, or Met) are also good substrates ...
Koert M. Dolman, Kam, Chih-Min, Kerrigan, John E., Roel Goldschmeding, Von dem Borne, Albert E.G.Kr., Kam, C. M., Powers, J. C., Chih-Min Kam, Albert E.G.Kr. Von dem Borne, Dolman, Koert M., von dem Borne, A. E., Powers, James C., Dolman, K. M., Kerrigan, J. E., James C. Powers, Goldschmeding, R., John E. Kerrigan, Goldschmeding, Roel   +17 more
core   +1 more source

Crystallization of the bifunctional proteinase/amylase inhibitor PKI-3 and of its complex with proteinase K [PDF]

, 1986
One of the three wheat germ inhibitors of proteinase K is bifunctional and inhibits simultaneously proteinase K (or subtilisin but not enzymes of the trypsin family) and insect α-amylase.
Gour P. Pal, Betzel, Christian, Pal, Gour P., Wolfram Saenger, Jany, Klaus-Dieter, Christian Betzel, Klaus-Dieter Jany, Saenger, Wolfram   +7 more
core   +1 more source

Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase

Molecules
Despite many years of research, human neutrophil elastase (HNE) still remains an area of interest for many researchers. This multifunctional representative of neutrophil serine proteases is one of the most destructive enzymes found in the human body ...
Karolina Torzyk-Jurowska, Jaroslaw Ciekot, Lukasz Winiarski   +2 more
doaj   +1 more source