Results 51 to 60 of about 18,213,481 (205)

Performance of two multiplex flow cytometric assays for antibody detection in Egyptian patients

African Journal of Laboratory Medicine, 2023
Background: Autoantibodies are vital biomarkers for the diagnosis, assessment and prognostic determination of various autoimmune disorders. Objective: This study aimed to evaluate the performance of the two AtheNA Multi-Lyte® systems for the detection ...
Alshymaa A. Ahmed, Alia A. El Shahaway, Heba M. Kadry, Nora M. Said   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Real-World Concordance of Indirect Immunofluorescence and Antigen-Specific Assays in Antineutrophil Cytoplasmic Antibody Testing: A Retrospective High-Volume Laboratory Study

Eurasian Journal of Medicine
Background: Current guidelines recommend myeloperoxidase (MPO)- and proteinase 3 (PR3)-based immunoassays as the primary approach for antineutrophil cytoplasmic antibody (ANCA) testing, while indirect immunofluorescence (IIF) is reserved for selected ...
Ayşe Arslan, Alper Togay
doaj   +1 more source

Optimizing conditions for enzymatic extraction of sunflower oil

Grasas y Aceites, 1992
Sunflower seed oil was extracted with an enzymatic processes using different hydrolytic enzymes: cellulase, hemicellulase, animal proteinase, acid proteinase, pectinase and pectinex, as compared to enzyme - free aqueous extraction.
F. H. Badr, M. Z. Sitohy
doaj   +1 more source

Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis

JCI Insight, 2021
BACKGROUND Little is known about the autoreactive B cells in antineutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis (AAV). We aimed to investigate tolerance checkpoints of circulating antigen-specific proteinase 3–reactive (PR3+) B ...
Alvise Berti, Sophie Hillion, Amber M. Hummel, Young Min Son, Nedra Chriti, Tobias Peikert, Eva M. Carmona, Wayel H. Abdulahad, Peter Heeringa, Kristina M. Harris, E. William St. Clair, Paul Brunetta, Fernando C. Fervenza, Carol A. Langford, Cees G.M. Kallenberg, Peter A. Merkel, Paul A. Monach, Philip Seo, Robert F. Spiera, John H. Stone, Guido Grandi, Jie Sun, Jacques-Olivier Pers, Ulrich Specks, Divi Cornec, for the RAVE-ITN Research Group   +25 more
doaj   +1 more source

Proteinase-3 antigen and thrombin activity in preterm BALF.

, 2014
Peak (a) proteinase-3 expression (nM) and (b) thrombin activity (mIU/ml) in BALF from No-BPD (circles, n = 9 for proteinase-3 antigen and n = 13 for thrombin activity) and BPD (squares, n = 8 for proteinase-3 antigen and n = 13 for thrombin activity ...
Brad Spiller (361218), Rachel C. Chambers (515058), Wendy Powell (669565), Sailesh Kotecha (402004), Salima Abdulla (669566), Philip L. Davies (669564), Mallinath Chakraborty (669563), John Hogwood (669568), Nikolai N. Voitenok (669567), Andrew Williams (247657), Eamon P. McGreal (614039), Elaine Gray (669569)   +11 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Building Blocks of 2,3-Diaminopropionic Acid Functionalized with an Oxa-Acid Spacer Shift the Functional Profile of Human Cathelicidin LL-37: Enhanced Enzymatic Stability and Selective Suppression of Neutrophil Degranulation

Pharmaceuticals
Background/Objectives: The human cathelicidin LL-37 (37 residues; net charge +6) couples broad-spectrum antimicrobial activity with immunomodulatory function, but rapid proteolysis and peptidylarginine deiminase (PAD)-mediated citrullination limit its ...
Wiktoria Rejmak, Katarzyna Bury, Marta Bauer, Wojciech Kamysz, Magdalena Wysocka, Adam Lesner   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Proteinase-activated receptors (PARs)

, 2008
Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4.
Plevin, Robin, Cunningham, Margaret Rose
core   +1 more source