Results 71 to 80 of about 18,213,481 (205)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Coffee cysteine proteinases and related inhibitors with high expression during grain maturation and germination

BMC Plant Biology, 2012
Background Cysteine proteinases perform multiple functions in seeds, including participation in remodelling polypeptides and recycling amino acids during maturation and germination.
Lepelley Maud, Amor Mohamed, Martineau Nelly, Cheminade Gerald, Caillet Victoria, McCarthy James   +5 more
doaj   +1 more source

Modulation by proteinase-3.

, 2014
Summary of processing of rhIL-877 by purified proteinase-3 showing recovery of total IL-8 (squares) and IL-877 (circles) and release of MMP-9 from neutrophils in response to the products of conversion (triangles).
Brad Spiller (361218), Rachel C. Chambers (515058), Wendy Powell (669565), Sailesh Kotecha (402004), Salima Abdulla (669566), Philip L. Davies (669564), Mallinath Chakraborty (669563), John Hogwood (669568), Nikolai N. Voitenok (669567), Andrew Williams (247657), Eamon P. McGreal (614039), Elaine Gray (669569)   +11 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow

Stem Cell Reports, 2018
Summary: Hematopoietic stem and progenitor cells (HSPCs) undergo self-renewal and differentiation to guarantee a constant supply of short-lived blood cells.
Kutay Karatepe, Haiyan Zhu, Xiaoyu Zhang, Rongxia Guo, Hiroto Kambara, Fabien Loison, Peng Liu, Hongbo Yu, Qian Ren, Xiao Luo, John Manis, Tao Cheng, Fengxia Ma, Yuanfu Xu, Hongbo R. Luo   +14 more
doaj   +1 more source

Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032)

, 1997
Click on the DOI link below to access the article (may not be free).The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated.
Groutas, William C., Hook, Jerry B., Ruan, Sumei, Kuang, Rongze, Sands, Howard   +4 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A novel in vitro cell model of the proteinase/antiproteinase balance observed in alpha-1 antitrypsin deficiency

Frontiers in Pharmacology
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting from mutations in the alpha-1 antitrypsin (AAT) protein, a major systemic antiproteinase, resulting in reduced/no release of AAT, disrupting the proteinase/antiproteinase ...
Celine H. Chen, Helena Crisford, Aaron Scott, Aaron Scott, Elizabeth Sapey, Elizabeth Sapey, Elizabeth Sapey, Robert A. Stockley, Robert A. Stockley   +8 more
doaj   +1 more source

Expression of proteinase 3 in PMNs.

, 2016
(A) Western blot of total PMN protein from 6 healthy controls (HC) and 6 patients with granulomatosis with polyangiitis (GPA). (B) Relative intensities of proteinase 3 following normalization to the corresponding β-actin intensity for the 6 HCs and 6 GPA
Bo Baslund (3226962), Nicolas Rapin (365497), Elisabeth Præstekjær Cramer (3226956), Jack Bernard Cowland (3226953), Jesper Brink Svendsen (3226959), Niels Borregaard (111002)   +5 more
core   +1 more source